ST13与肾透明细胞癌患者预后及免疫浸润的相关性分析  

Correlation analysis of ST13 with prognosis and immune infiltration in patients with kidney renal clear cell carcinoma

作　　者：郑佳薇 余然杰 宋丽 欧阳学农 ZHENG Jia-wei(School of Basic Medical Science,Putian University,Putian 351100,Fujian,China)

机构地区：[1]莆田学院基础医学院,福建莆田351100 [2]福建医科大学附属协和医院重症医学科,福建福州350001 [3]联勤保障部队第900医院肿瘤科,福建福州350025

出　　处：《牡丹江医学院学报》2024年第6期69-73,共5页Journal of Mudanjiang Medical University

基　　金：福建省教育厅中青年教师教育科研项目(JT180482)。

摘　　要：目的 利用生物信息学探究肿瘤抑制基因13(Suppression of Tumorigenicity13,ST13)在肾透明细胞癌中的表达及其与肿瘤预后、免疫浸润的关系。方法 利用仙桃学术、阿拉巴马大学伯明翰分校癌症数据分析门户网站(The University of Alabama at Birmingham Cancer Data Analysis Portal,UALCAN)、人类蛋白质图谱数据库(Human Protein Atlas Database,HPA)数据库分析ST13在肾透明细胞癌患者中的表达情况;利用UALCAN分析ST13与肾透明细胞癌患者临床病理特征的关系;通过Kaplan-Meier Plotter、基因表达谱交互分析2(Gene Expression Profiling Interactive Analysis 2,GEPIA2)数据库分析ST13表达变化对肾透明细胞癌患者生存率的影响;通过肿瘤免疫评估资源(Tumor Immune Estimation Resource,TIMER)数据库分析ST13与免疫浸润的相关性。结果 ST13在肾透明细胞癌组织中低表达;ST13表达量与患者的肿瘤分期、人种、肿瘤分级、肾透明细胞癌亚型和淋巴结转移情况相关(P<0.05);在肾透明细胞癌患者中,ST13高表达者较低表达者具有更好的总生存率和无病生存率;ST13表达水平与B细胞、CD8^(+) T细胞、巨噬细胞、中性粒细胞和树突状细胞的浸润水平呈正相关。结论 ST13在肾透明细胞癌中高表达标志着更好的预后,并可能通过调节免疫浸润程度而影响肿瘤微环境,其有望成为肾透明细胞癌的生物标志物和潜在的治疗靶点。Objective To investigate the expression of suppression of tumorigenicity 13(ST13) in kidney renal clear cell carcinoma(KIRC) and its association with tumor prognosis and immune infiltration using bioinformatics approaches.Methods The expression of ST13 in KIRC patients was analyzed using the Xiantao Academic platform,The University of Alabama at Birmingham Cancer Data Analysis Portal(UALCAN),and the Human Protein Atlas(HPA) database.UALCAN was used to analyze the relationship between ST13 expression and clinicopathological features of KIRC patients.Kaplan-Meier Plotter and GEPIA2 were used to analyze the effects of ST13 expression on the survival rate of KIRC patients.The correlation between ST13 expression and immune infiltration was analyzed through the Tumor Immune Estimation Resource(TIMER) database.Results ST13 expression was found to be low in KIRC.The expression of ST13 was correlated with tumor stage,race,tumor grade,KIRC subtypes and lymph node metastasis status(P<0.05).Patients with higher ST13 expression exhibited better overall survival and disease-free survival compared to those with lower ST13 expression.The expression level of ST13 was positively correlated with the infiltration levels of B cells,CD8^(+) T cells,macrophages,neutrophils and dendritic cells.Conclusion Elevated ST13 expression is indicative of a more favorable prognosis in KIRC and may influence the tumor microenvironment by regulating the extent of immune infiltration.ST13 is expected to become a biomarker and potential therapeutic target for KIRC.

关 键 词：肾透明细胞癌 生物信息学 ST13 预后 免疫浸润 

分 类 号：R737.11[医药卫生—肿瘤]