PPP1R14B在子宫内膜癌组织中的表达及其临床意义  

Expression and clinical significance of PPP1R14B in endometrial cancer tissues

作　　者：林莉莉 庄英[1] 杜双雪 王喜纬 段霞[1] LIN Lili;ZHUANG Ying;DU Shuangxue;WANG Xiwei;DUAN Xia(Department of Gynecology,Affiliated Hospital of Obstetrics and Gynecology,Tongji University,Shanghai 200040,China;Department of Gynecology,the First Affiliated Hospital of Naval Medical University,Shanghai 200433,China;Department of Gynecology,Zhoupu Hospital,Pudong New Area,Shanghai 200120,China)

机构地区：[1]同济大学附属妇产科医院妇科,上海200040 [2]海军军医大学第一附属医院妇科,上海200433 [3]上海市浦东新区周浦医院妇科,上海200120

出　　处：《现代肿瘤医学》2024年第24期4632-4637,共6页Journal of Modern Oncology

摘　　要：目的:研究蛋白磷酸酶1调节亚基14B(protein phosphatase1 regulatory subunit 14B,PPP1R14B)在子宫内膜癌组织中的表达情况,并探讨其临床意义。方法:收集本院85例作为研究对象,术中收集患者的癌组织和癌旁组织,免疫组化法检测PPP1R14B蛋白表达,RT-qPCR检测PPP1R14B mRNA表达水平,分析PPP1R14B表达与临床病理特征的关系,采用Kaplan-Meier法分析PPP1R14B表达与患者生存率的关系,多因素Cox回归分析影响子宫内膜癌患者预后的危险因素。结果:子宫内膜癌组织中PPP1R14B阳性表达率及PPP1R14B mRNA表达明显高于癌旁组织(P<0.05);PPP1R14B表达与年龄、病理分级、FIGO分期、淋巴结转移、组织分化程度有关(P<0.05);PPP1R14B mRNA高表达患者5年生存率显著低于PPP1R14B mRNA低表达患者(P<0.05);且年龄、病理分级、FIGO分期、淋巴结转移和PPP1R14B高表达水平是预后独立危险因素(P<0.05)。结论:PPP1R14B在子宫内膜癌患者组织中高表达,与年龄、病理分级、FIGO分期、淋巴结转移和预后密切相关,是影响患者预后的重要因素。Objective:To investigate the expression of PPP1R14B and its clinical significance.Methods:85 cases were collected as the research subjects in this study.The cancer tissue and adjacent tissue of patients were collected during surgery.Immunohistochemistry was used to detect the expression of PPP1R14B protein.RT-qPCR was used to detect the expression level of PPP1R14B mRNA,and the relationship between PPP1R14B expression and clinical pathological characteristics was analyzed.Kaplan-Meier method was used to analyze the relationship between PPP1R14B expression and survival rate of patient.Multivariate Cox regression analysis was conducted to identify risk factors affecting the prognosis of endometrial cancer patients.Results:The positive expression rate and mRNA expression of PPP1R14B in endometrial cancer tissues were significantly higher than those in adjacent tissues(P<0.05).The expression of PPP1R14B was related to age,pathological grading,FIGO staging,lymph node metastasis,and tissue differentiation degree(P<0.05).The 5-year survival rate of patients with high PPP1R14B mRNA expression was significantly lower than that in low PPP1R14B mRNA expression(P<0.05).Age,pathological grade,FIGO staging,lymph node metastasis,and high expression level of PPP1R14B were independent prognostic risk factors(P<0.05).Conclusion:PPP1R14B is highly expressed in the tissue of patients with endometrial cancer,which is closely related to age,pathological classification,FIGO staging,lymph node metastasis,and the prognosis of patients,which is an important factor affecting the prognosis of patients.

关 键 词：子宫内膜癌 PPP1R14B 临床病理特征 预后 诊断价值 

分 类 号：R737.33[医药卫生—肿瘤]