重组人白介素-2局部给药治疗体表转移性肿瘤的疗效及对改善患者焦虑的影响  

The efficacy of recombinant interleukin-2 peritumoral injection on local tumor responsiveness and its effect on subsquent symptomatic anxiety improvement

作　　者：荣秀梅 徐大钊 霍菲菲 耿振英 林萍 赵海洋 吴铁成 王小利 RONG Xiumei;XU Dazhao;HUO Feifei;GENG Zhenying;LIN Ping;ZHAO Haiyang;WU Tiecheng;WANG Xiaoli(Department of Oncology,Beijing Zhongguancun Hospital(Zhongguancun Hospital,Chinese Academy of Sciences),Beijing 100190,China)

机构地区：[1]北京市中关村医院(中国科学院中关村医院)肿瘤科,北京0x09100190

出　　处：《现代肿瘤医学》2024年第24期4649-4653,共5页Journal of Modern Oncology

基　　金：北京市海淀区卫生健康发展科研培育计划项目(编号:HP2022-19-201001)。

摘　　要：目的:分析重组人白介素-2(recombinant interleukin-2,rIL-2)对体表恶性肿瘤瘤周注射的疗效,同时分析其对患者生活质量、焦虑抑郁情绪的影响。方法:回顾性分析2022年01月至2024年02月我院肿瘤科诊治的体表恶性肿瘤患者24例,平均年龄75.5岁,经过三位医生讨论及患者本人的意见不适合化疗,采用rIL-2在瘤周皮下注射,第1~3周每次剂量为50万国际单位/平方米(IU/m^(2)),第5~7周每次剂量为100万IU/m^(2),治疗结束后评估肿瘤大小、生活质量(quality of life,QOL)评分、焦虑自评量表(self-rating anxiety scale,SAS)评分、抑郁自评量表(self-rating depressions scale,SDS)评分变化。结果:观察病例经rIL-2治疗后局部肿物的疾病控制率为91.7%。rIL-2先后以50万IU/m^(2)、100万IU/m^(2)治疗后:①肿瘤最大直径有所缩小,前后比较差异无统计学意义(P>0.05);②QOL评分明显升高,差异具有统计学意义(P<0.05);③焦虑、抑郁病例数量、程度均有下降,治疗前后比较差异具有统计学意义(P<0.05)。结论:对于高龄不适合全身给药化疗的患者,皮下肿物的局部rIL-2瘤周注射治疗,可以提高肿瘤的局部控制率,给予患者增强治疗的信心,进而显著改善患者生活质量,降低患者焦虑、抑郁发生率及严重程度。Objective:To analyze the disease control effect of recombinant interleukin-2(rIL-2)via peritumoral injected on superficial tumors which were associated with systematic improvement on life quality,anxiety and depression.Methods:24 patients with average age of 75.5 years old who were not eligiable for standard chemotherapy were enrolled with superficial tumors treated in our hospital were retrospectively studied January 2022 to February 2024.rIL-2 was administrated via peritumoral injectived on superficial tumors with an initial dose of 500000 IU/m 2 for conseutive three weeks followed by escalation up to 1000000 IU/m 2 at the fifth to seventh weeks.The tumor size,the score of quality of life(QOL),self-rating anxiety scale(SAS),self-rating depressions scale(SDS)were recorded.Results:The disease control rate(DcR)of patients included was 91.7%after therapy of rIL-concurrent with the decreased tumor size(P>0.05).The score of QoL was improved(P<0.05)with contrast to lowered severity of anxiety and depression(P<0.05)when the dose of rIL-2 enhanced from 500000 IU/m 2 to 1000000 IU/m 2.Conclusion:The alternative administration of rIL-2 peritumoral injected on superficial tumors as minicking systemic anti-cancer therapy could improve the quality of life as effective supporting care for those aged patients.

关 键 词：重组人白介素-2 体表恶性肿瘤 疗效 焦虑 

分 类 号：R730.5[医药卫生—肿瘤]