DDB2在癌症发生发展过程中的分子机制  

The molecular mechanism of DDB2 in the occurrence and development of cancer

作　　者：周文倩 赵文剑 郭九茹 王樑 ZHOU Wenqian;ZHAO Wenjian;GUO Jiuru;WANG Liang(Tangdu Hospital,Air Force Medical University,Shaanxi Xi'an 710038,China;Four Brigades of the School of Basic Medicine,Air Force Medical University,Shaanxi Xi'an 710032,China)

机构地区：[1]空军军医大学唐都医院,陕西西安710038 [2]空军军医大学基础医学院学员四大队,陕西西安710032

出　　处：《现代肿瘤医学》2024年第24期4680-4686,共7页Journal of Modern Oncology

基　　金：陕西省杰出青年科学基金项目(编号:2023-JC-JQ-68);陕西省高校青年创新团队项目(编号:2022-61)。

摘　　要：损伤特异性DNA结合蛋白2(damage-specific DNA binding protein 2,DDB2)是损伤特异性DNA结合异二聚体复合物的一个组成部分,与其他蛋白质合作修复紫外线诱导的DNA损伤,通过影响核苷酸切除修复(nucleotide excision repair,NER)、细胞凋亡和过早衰老参与癌症的发生和发展,并且影响癌细胞对放疗和化疗的敏感性。多项研究发现DDB2参与结直肠癌、胃癌、乳腺癌等癌症癌变的进程,并在肿瘤抑制中发挥着关键作用。该文就涉及DDB2的不同生物过程的分子机制进行综述,以求为研究靶向DDB2的药物提供理论支持。Damage-specific DNA binding protein 2(DDB2)is a component of the damage-specific DNA binding heterodimer complex.It cooperates with other proteins to repair UV-induced DNA damage,participates in the occurrence and development of cancer by affecting nucleotide excision repair(NER),apoptosis and premature aging,and affects the sensitivity of cancer cells to radiotherapy and chemotherapy.A number of studies have found that DDB2 is involved in the carcinogenesis of colorectal cancer,gastric cancer,breast cancer and other cancers,and plays a key role in tumor inhibition.This article reviews the molecular mechanisms of different biological processes involving DDB2,in order to provide theoretical support for the study of drugs targeting DDB2.

关 键 词：损伤特异性DNA结合蛋白2 紫外线损伤DNA结合蛋白 核苷酸切除修复 癌症 进展 

分 类 号：R730.231[医药卫生—肿瘤]