肾上腺素受体在肿瘤中的研究进展  

Advances in research on adrenergic receptors in cancer

作　　者：沈世雄 丁萌萌 韩佳轩 孟心语 刘媛 初明[1,3,4] 李民[2] 王月丹 SHEN Shixiong;DING Mengmeng;HAN Jiaxuan;MENG Xinyu;LIU Yuan;CHU Ming;LI Min;WANG Yuedan(Department of Immunology,School of Basic Medical Sciences,Peking University,Beijing 100191,China;Department of Anesthesiology,Peking University Third Hospital,Beijing 100191,China;Key Laboratory of Medical Immunology,National Health Commission,Beijing 100191,China;Comprehensive Laboratory of Pathogens and Immunology,Biomedical Experimental Teaching Center,Peking University,Beijing 100191,China)

机构地区：[1]北京大学基础医学院免疫学系,北京100191 [2]北京大学第三医院麻醉科,北京100191 [3]国家卫生健康委员会医学免疫学重点实验室,北京100191 [4]北京大学生物医学实验教学中心病原与免疫综合实验室,北京100191

出　　处：《现代肿瘤医学》2024年第23期4522-4530,共9页Journal of Modern Oncology

基　　金：国家重点研发项目(编号:SQ2021YFE020462)。

摘　　要：肾上腺素受体在免疫细胞上有显著表达,近年来,许多研究愈发关注其在免疫调节中的重要作用。在肿瘤领域,多项研究指出肾上腺素受体可能成为肿瘤治疗的新靶点:α肾上腺素受体通过调节免疫细胞的迁移和细胞因子的分泌,影响肿瘤的生长与转移,而β肾上腺素受体则在肿瘤微环境中介导免疫抑制性信号通路,显著影响肿瘤的免疫逃逸机制。对肾上腺素受体在肿瘤中的作用研究,不仅有助于深入理解肿瘤免疫调控机制,还为开发新的肿瘤免疫治疗策略提供了理论依据。该文重点综述了近几年肾上腺素受体在肿瘤中的研究进展,并讨论其在肿瘤免疫调控中的关键作用和应用潜力,同时整合了肾上腺素受体的蛋白三维结构,总结了肾上腺素受体的调节剂及其主要效应,以及部分肾上腺素受体激动药和拮抗药对肿瘤治疗的影响。Adrenergic receptors are prominently expressed on immune cells,and recent studies have increasingly highlighted their critical role in immunoregulation.In oncology,numerous studies have identified adrenergic receptors as potential novel targets for cancer therapy.Specifically,α-adrenergic receptors influence cancer growth and metastasis by modulating immune cell migration and cytokine secretion,whileβ-adrenergic receptors play a significant role in cancer immune evasion by mediating immunosuppressive signaling pathways within the tumor microenvironment.Research on the role of adrenergic receptors in cancer not only deepens our understanding of cancer immunoregulation mechanisms but also provides a theoretical basis for developing novel cancer immunotherapy strategies.This paper reviews recent advances in the study of adrenergic receptors in cancer,discussing their key roles and potential applications in cancer immune regulation.It also examines the three-dimensional structure of adrenergic receptor proteins,summarizes the regulators of adrenergic receptors and their primary effects,and compiles the impact of certain adrenergic receptor agonists and antagonists on cancer treatment.

关 键 词：肾上腺素受体 免疫调控 免疫治疗 信号转导 肿瘤治疗 

分 类 号：R730.5[医药卫生—肿瘤]