PDT机制及在肺癌中的应用  

Mechanism of PDT and its application in lung cancer

作　　者：李祥振 刘天军[2] LI Xiangzhen;LIU Tianjun(Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;Tianjin Key Laboratory of Biomedical Materials,Institute of Biomedical Engineering,Chinese Academy of Medical Sciences and Peking Union Medical College,Tianjin 300192,China)

机构地区：[1]天津中医药大学,天津301617 [2]中国医学科学院北京协和医学院生物医学工程研究所,天津市生物医学材料重点实验室,天津300192

出　　处：《现代肿瘤医学》2024年第23期4531-4538,共8页Journal of Modern Oncology

基　　金：天津市科技支撑计划重点项目(编号:20YFZCSY00570);首都卫生发展科研专项(编号:2022-1-4041);中国医学科学院医学与健康科技创新工程(编号:2021-I2M-1-015)。

摘　　要：肺癌是一种最为常见的癌症,近年来一种新型的治疗方式—光动力疗法(photodynamic therapy,PDT)受到了广泛关注。与传统的治疗方式相比,PDT对肿瘤细胞具有更强的选择性,这是由于使用的光敏剂可以更好地定位在肿瘤病变中,通过细胞凋亡或坏死和破坏肿瘤血管直接杀伤细胞。该文主要介绍了PDT的原理及机制、在亚细胞定位的研究和在肺癌中的应用,并介绍了PDT面临的挑战及展望。Lung cancer is one of the most common cancers,and a new type of treatment-photodynamic therapy(PDT),has received a lot of attention in recent years.Compared with traditional therapies,PDT is more selective to tumor cells because the photosensitizers used can be better positioned in tumor lesions to directly kill cells through apoptosis or necrosis and destruction of tumor blood vessels.This review mainly introduces the principle and mechanism of PDT,the research on subcellular localization and its application in lung cancer,and introduces the challenges and prospects of PDT.

关 键 词：光动力疗法 光敏剂 肺癌 亚细胞定位 

分 类 号：R734.2[医药卫生—肿瘤]