Nanozymes regulated by nitrogen element:Mechanism,design,and application  

作　　者：Longhua Ding Longwei Wang Jian Zhang Na Ren Aizhu Wang Hong Liu Xin Yu 

机构地区：[1]Institute for Advanced Interdisciplinary Research(iAIR),School of Chemistry and Chemical Engineering,University of Jinan,Jinan 250022,China [2]CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety&CAS Center for Excellence in Nanoscience,National Center for Nanoscience and Technology of China,University of Chinese Academy of Science,Beijing 100190,China [3]Division of Systems and Synthetic Biology,Department of Life Sciences,Chalmers University of Technology,41296,Göoteborg,Sweden [4]State Key Laboratory of Crystal Materials,Shandong University,Jinan 250100,China [5]Key Laboratory of Optic-electric Sensing and Analytical Chemistry for Life Science,MOE,Qingdao University of Science and Technology,Qingdao 266042,China

出　　处：《Advanced Powder Materials》2024年第4期9-26,共18页先进粉体材料（英文）

基　　金：supported by the Taishan Scholar Project of Shandong Province(tsqn202211168,tsqn202312247);the National Natural Science Foundation of China(52272212);the Natural Science Foundation of Shandong Province(ZR2022JQ20,ZR2021YQ04,ZR2023MB126);the Key Laboratory of Optic-electric Sensing and Analytical Chemistry for Life Science,MOE(M2022-7).

摘　　要：Nanozymes,a category of nanomaterials endowed with enzyme-mimicking capabilities,have exhibited considerable potential across diverse application domains.This comprehensive review delves into the intricacies of regulating nanozymes through N elements,elucidating the mechanisms governing N element control in the design and application of these nanomaterials.The initial sections introduce the foundational background and significance of nanozymes.Subsequent exploration delves into the detailed discussion of N element regulation mechanisms on nanozymes,encompassing N vacancies,N doping,N coordination,and nitride.These regulatory pathways play an instrumental role in fine-tuning the catalytic activity and specificity of nanozymes.The review further scrutinizes practical applications of N element regulation on nanozymes,spanning sensing detection,infection therapy,tumor therapy,and pollutant degradation.In conclusion,it succinctly summarizes the current research findings and proposes future directions for development.This thorough investigation into the regulation of nanozymes by N elements anticipates precise control over their performance,thereby advancing the extensive utilization of nanozymes in the realms of biomedical and environmental applications.

关 键 词：Nnanozyme Nitrogen doping Nitrogen corrdination Infection therapy Tumor therapy 

分 类 号：R73[医药卫生—肿瘤]