Trends in epidemiological characteristics and etiologies of diarrheal disease in children under five:an ecological study based on Global Burden of Disease study 2021  

作　　者：Chu Chu Guobing Yang Jian Yang Defeng Liang Ruitao Liu Guanhua Chen Jichun Wang Guisheng Zhou Hongli Wang 

机构地区：[1]National Key Laboratory on Technologies for Chinese Medicine Pharmaceutical Process Control and Intelligent Manufacture,Nanjing University of Chinese Medicine,Nanjing 210023,Jiangsu,China [2]Gansu Provincial Center for Disease Control and Prevention,Lanzhou 730000,Gansu,China [3]Chinese Center for Disease Control and Prevention,National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases,Beijing 102206,China [4]Guangzhou Women and Children's Medical Center,Guangzhou Medical University,Guangzhou 510623,Guangdong,China

出　　处：《Science in One Health》2024年第1期229-241,共13页全健康科学（英文）

基　　金：supported by the fund of Shanghai Natural Science Foundation(grant number 23ZR1464000);the Talent Fund of Longhua Hospital affiliated to Shanghai University of Traditional Chinese Medicine(grant number LH001.007);the Science and Technology Support Project of Taizhou city(SSF20210070).

摘　　要：Background:Diarrhea remains a significant health threat to children under five years of age.The study aims to systematically elucidate the global burden of diarrhea in children,providing scientific insights for effective prevention and control strategies.Methods:The data from the Global Burden of Disease(GBD)2021 study was analyzed to assess the trends in incidence,prevalence,mortality,and disability-adjusted life years(DALYs)of diarrhea in children under five years across the globe,21 geographical region,and 204 countries and territories,stratified by age group,sex,and socio-demographic index(SDI)levels.The trend of the disease burden for childhood diarrhea from 1990 to 2021 was described and estimated using the average annual percent change(AAPC),and a Bayesian age-period-cohort(BAPC)model was employed to predict the future burden of diarrhea in children.Results:From 1990 to 2021,there was a significant decline in the global burden of diarrhea among children under five years of age.The AAPC for incidence(-4092.18,95%confidence interval[CI]:-4224.60 to-3959.76),prevalence(-70.98,95%CI:-72.67 to-69.28),mortality(-6.89,95%CI:-6.95 to-6.83),and DALYs rate(-621.79,95%CI:-627.20 to-616.38)of diarrhea in children all showed a marked downward trend.Diarrheal incidence(r=-0.782,P<0.001),prevalence(r=-0.777,P<0.001),mortality(r=-0.908,P<0.001),and DALYs rate(r=-0.904,P<0.001)were negatively correlated with the SDI.Between 2022 and 2035,the global incidence,prevalence,and mortality rates of diarrhea in children under five years are projected to continue declining.The leading causes of diarrheal mortality in children include wasting,underweight,and non-exclusive breastfeeding.Rotavirus remains the predominant pathogen associated with diarrhea-related mortality rate and DALY rate.Conclusion:Although the global burden of diarrhea in children under five has steadily declined,it remains a significant health threat.Rotavirus is the leading pathogen,highlighting the importance of expanding rotavirus vaccination.Additionally,impr

关 键 词：Diarrheal disease CHILDREN Global Burden of Disease study 2021 Projections One Health 

分 类 号：R57[医药卫生—消化系统]