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作 者:周婷[1] 黎娟 王慧[3] 杨旭 ZHOU Ting;LI Juan;WANG Hui;YANG Xu(Clinical Medicine School,North Sichuan Medical College,Sichuan Province,Nanchong637000,China;Department of Obstetrics and Gynecology,Chengdu Fifth People’s Hospital,Sichuan Province,Chengdu611130,China;Center for Medicine Research and Translation,Chengdu Fifth People’s Hospital,Sichuan Province,Chengdu611135,China)
机构地区:[1]川北医学院临床医学院,四川南充637000 [2]成都市第五人民医院妇产科,四川成都611130 [3]成都市第五人民医院医学研究与转化中心,四川成都611135
出 处:《中国医药导报》2024年第28期72-76,共5页China Medical Herald
基 金:四川省科技计划项目(2022JDRC0141);四川省医学科研课题计划项目(S22098);四川省成都市医学科研课题(2023044)。
摘 要:卵巢癌是妇科三大恶性肿瘤之一,死亡率居妇科恶性肿瘤之首,严重威胁女性生命健康。确诊时间晚、化疗耐药及易复发是造成卵巢癌高死亡率的主要原因。故卵巢癌的早期诊断和个性化治疗具有重大意义。微核糖核酸(miRNA)是一类内源性非编码单链小RNA,通过转录后水平调控靶基因表达参与细胞正常生理功能的调节及肿瘤的发生和发展。miR-200家族是miRNA研究较深入的1个分支,已被证实在多种癌症中表达失调。针对卵巢癌研究发现,miR-200家族与卵巢癌增殖、凋亡、侵袭、迁移和化疗耐药等生物学过程密切相关。本文对miR-200家族在卵巢癌中表达及其与癌症恶性进展、耐药性的关系进行综述,以期为卵巢癌的早期诊断和精准治疗提供新策略。Ovarian cancer is one of the three major malignant tumors in gynecology,and its death rate is the highest among gynecological malignant tumors,seriously threatening women’s life and health.Late diagnosis,chemotherapy resistance,and ease of recurrence are the main reasons for high mortality rate of ovarian cancer.Therefore,early diagnosis and personalized treatment of ovarian cancer are of great significance.MicroRNA(miRNA)is a type of endogenous non-coding single-stranded small RNA that are involved in the regulation of normal cellular physiological functions and tumorigenesis and development by regulating the expression of target genes at the post-transcriptional level.The miR-200 family is one of the more intensively studied branches of miRNA and has been shown to be dysregulated in expression in a variety of cancers.Research on ovarian cancer has found that miR-200 family is closely related to biological processes such as proliferation,apoptosis,invasion,migration,and chemotherapy resistance in ovarian cancer.This article reviews the expression of miR-200 family in ovarian cancer and its relationship with malignant progression and drug resistance,in order to provide new strategies for early diagnosis and precise treatment of ovarian cancer.
关 键 词:卵巢癌 微核糖核酸 微核糖核酸-200家族 上皮-间充质转化
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