针灸治疗创伤性颅脑损伤的机制研究进展  

Research progress on mechanism of acupuncture and moxibustion in the treatment of traumatic brain injury

作　　者：韩沂晓 王东岩[2] 王春霞[2] 霍宏[2] 周以皓 刘月 夏雪 杨俊驰 HAN Yixiao;WANG Dongyan;WANG Chunxia;HUO Hong;ZHOU Yihao;LIU Yue;XIA Xue;YANG Junchi(Graduate School,Heilongjiang University of Chinese Medicine,Heilongjiang Province,Harbin150040,China;Department of Acupuncture,Second Affiliated Hospital of Heilongjiang University of Chinese Medicine,Heilongjiang Province,Harbin150000,China)

机构地区：[1]黑龙江中医药大学研究生院,黑龙江哈尔滨150040 [2]黑龙江中医药大学附属第二医院针灸科,黑龙江哈尔滨150000

出　　处：《中国医药导报》2024年第27期39-44,共6页China Medical Herald

基　　金：国家自然科学基金面上项目(82374601);黑龙江省中医药科研项目(ZHY2023-161)。

摘　　要：创伤性颅脑损伤(TBI)是全球性的公共卫生挑战,具有高发病率、高致死率和高致残率。近年来,针灸因其独特疗效在TBI的临床治疗中被广泛应用,但对其作用机制的探讨相对较少。本文通过梳理近5年针灸治疗TBI的相关研究发现,针灸可通过促进神经修复与再生、抗炎及调节细胞凋亡、细胞自噬、突触可塑性和细胞能量代谢等多靶点改善TBI的临床症状。但仍缺乏系统深入高质量的研究,未来研究应围绕血脑屏障保护、脑肠轴等热点研究更深入探索针灸起效机制,为阐明针灸治疗TBI的潜在作用提供科学依据。Traumatic brain injury(TBI)is a global public health challenge with a high incidence rate,mortality rate,and disability rate.In recent years,acupuncture and moxibustion has been widely used in clinical treatment of TBI due to its unique efficacy,but there is relatively little discussion on its mechanism of action.This article reviews relevant research findings of acupuncture and moxibustion in the treatment of TBI in the past five years,and finds that acupuncture and moxibustion can improve clinical symptoms of TBI through multiple targets such as promoting neural repair and regeneration,anti-inflammation,regulating cell apoptosis,cell autophagy,synaptic plasticity,and cellular energy metabolism.However,there is still a lack of systematic and in-depth high-quality research.Future research should focus on hot topics such as blood-brain barrier protection and brain-gut axis to explore the mechanism of acupuncture and moxibustion,providing scientific evidence for clarifying the potential role of acupuncture in the treatment of TBI.

关 键 词：针灸 创伤性颅脑损伤 机制 综述 

分 类 号：R742[医药卫生—神经病学与精神病学]