溶瘤病毒抗肿瘤的作用机制及其在骨肉瘤治疗中的研究进展  

Anti-tumor mechanism of oncolytic virus and its research progress in the treatment of osteosarcoma

作　　者：刘茂荣 同志超[2] LIU Maorong;TONG Zhichao(The Second Clinical College,Shaanxi University of Chinese Medicine,Shaanxi Province,Xianyang712046,China;Department of Orthopaedic Oncology,Honghui Hospital Affiliated Xi’an Jiaotong University,Shaanxi Province,Xi’an710054,China)

机构地区：[1]陕西中医药大学第二临床医学院,陕西咸阳712046 [2]西安交通大学附属红会医院骨病肿瘤科,陕西西安710054

出　　处：《中国医药导报》2024年第27期70-73,共4页China Medical Herald

基　　金：陕西省西安市科技计划项目[2019115013YX005SF038(13)]。

摘　　要：骨肉瘤是一种骨组织原发性恶性肿瘤,常好发于儿童和青少年,一般可产生局部疼痛、肿胀和活动畸形等临床症状。目前手术切除和化疗是骨肉瘤的常见治疗类型,但由于其高度恶性、耐药性、易复发及易远处转移的特点,临床治疗效果并不理想。近年来,溶瘤病毒作为一种新型的免疫治疗手段参与肿瘤治疗,已成为骨肉瘤研究的新方向。本文旨在综述溶瘤病毒的定义和分类、抗肿瘤机制、治疗骨肉瘤研究进展及与其他疗法协同治疗骨肉瘤的效果,为骨肉瘤提供新的治疗思路。Osteosarcoma is a primary malignant tumor of bone tissue,which often occurs in children and adolescents,and generally produces clinical symptoms such as local pain,swelling and active deformity.At present,surgical resection and chemotherapy are common treatment types for osteosarcoma,but due to its high malignancy,drug resistance,easy recurrence and distant metastasis,clinical treatment effect is not ideal.In recent years,oncolytic viruses have become a new direction in the research of osteosarcoma as a novel immunotherapy approach involved in tumor treatment.This article aims to review definition and classification of oncolytic viruses,anti-tumor mechanisms,research progress in the treatment of osteosarcoma,and the efficacy of synergistic treatment with other therapies for osteosarcoma,providing new treatment ideas for osteosarcoma.

关 键 词：溶瘤病毒 骨肉瘤 治疗进展 溶瘤机制 联合治疗 

分 类 号：R738.1[医药卫生—肿瘤]