红细胞压积、降钙素原、白蛋白检测对急性胰腺炎严重程度及预后的临床意义分析  

Analysis of the clinical significance of hematocrit,procalcitonin,and albumin detection on the severity and prognosis of acute pancreatitis

作　　者：苏敏仪 成小英 王陆荣 SU Min-yi;CHENG Xiao-ying;WANG Lu-rong(Dongguan Fenggang Hospital,Dongguan 523000,China)

机构地区：[1]东莞市凤岗医院,523000

出　　处：《中国现代药物应用》2024年第22期27-30,共4页Chinese Journal of Modern Drug Application

摘　　要：目的 分析红细胞压积、降钙素原、白蛋白检测对急性胰腺炎严重程度及预后的临床意义。方法 146例急性胰腺炎患者,依照病情严重程度分为观察组(80例)和对照组(66例);根据患者随访28 d的预后结局不同分为预后良好组(134例)和预后不良组(12例)。对比观察组与对照组患者的白蛋白、降钙素原以及红细胞压积,预后良好组与预后不良组患者的白蛋白、降钙素原以及红细胞压积;分析白蛋白、降钙素原以及红细胞压积对急性胰腺炎患者病情严重程度的预测价值,白蛋白、降钙素原、红细胞压积单独检测以及三项指标联合检测对急性胰腺炎患者预后的预测价值。结果 观察组患者的白蛋白(35.12±7.22)g/L、红细胞压积(39.55±7.30)%低于对照组的(39.44±6.23)g/L、(41.71±4.36)%,降钙素原(2.16±0.11)ng/ml高于对照组的(0.91±0.05)ng/ml,差异明显(P<0.05)。预后不良组患者白蛋白(34.05±4.22)g/L、红细胞压积(34.26±6.23)%低于预后良好组的(37.34±4.56)g/L、(41.09±5.22)%,降钙素原(3.52±0.13)ng/ml高于预后良好组的(1.42±0.06)ng/ml,差异明显(P<0.05)。降钙素原预测急性胰腺炎病情严重程度的截断值为1.78 ng/ml,曲线下面积(AUC)为0.886,特异度与敏感度分别为93.12%、79.52%;白蛋白截断值为36.43 g/L,AUC为0.876,特异度与敏感度分别为93.08%、78.86%;红细胞压积截断值为36.78%,AUC为0.678,特异度与敏感度分别为48.23%、72.11%。红细胞压积预测急性胰腺炎不良预后的截断值为35.86%,AUC为0.771,特异度、敏感度分别为85.02%、68.78%;降钙素原截断值为1.98 ng/ml,AUC为0.819,特异度、敏感度分别为89.29%、74.36%;白蛋白截断值为35.61 g/L,AUC为0.813,特异度、敏感度分别为88.51%、74.12%;三项指标联合检测的AUC为0.921,特异度、敏感度分别为96.02%、71.20%。三项指标联合检测对急性胰腺炎不良预后的预测价值较白蛋白、降钙素原以及红细胞压积单独检测更�Objective To analyze the clinical significance of hematocrit,procalcitonin,and albumin detection on the severity and prognosis of acute pancreatitis.Methods A total of 146 patients with acute pancreatitis were selected and divided into an observation group(80 cases) and a control group(66 cases) based on the severity of their condition.The patients were divided into good prognosis group(134 cases) and bad prognosis group(12 cases) according to the different prognosis of 28 d of follow-up.The levels of albumin,procalcitonin and hematocrit were compared between the observation group and the control group,the good prognosis group and the poor prognosis group.The predictive value of albumin,procalcitonin and hematocrit alone and in combination in patients with acute pancreatitis was analyzed.Results The observation group had albumin of(35.12±7.22) g/L and hematocrit of(39.55±7.30) %,which were lower than(39.44±6.23) g/L and(41.71±4.36) % in the control group;the procalcitonin of(2.16±0.11) ng/ml in the observation group was higher than(0.91±0.05) ng/ml in the control group;the difference was significant(P<0.05).The poor prognosis group had albumin of(34.05±4.22) g/L and hematocrit of(34.26±6.23) %,which were lower than(37.34±4.56) g/L and(41.09±5.22) % in the good prognosis group;the procalcitonin of(3.52±0.13) ng/ml in the poor prognosis group was higher than(1.42±0.06) ng/ml in the good prognosis group;the difference was significant(P<0.05).The cut-off point of procalcitonin in predicting the severity of acute pancreatitis was 1.78 ng/ml,the area under the curve(AUC) was 0.886,with a specificity and sensitivity of 93.12% and 79.52%;the cut-off point of albumin was 36.43 g/L,AUC was 0.876,with a specificity and sensitivity of 93.08% and 78.86%;the cut-off point of hematocrit was 36.78%,AUC was 0.678,with a specificity and sensitivity of 48.23% and 72.11%.The cut-off point of hematocrit in predicting poor prognosis of acute pancreatitis was 35.86%,AUC was 0.771,with a specificity and sensitivity of 85.02%

关 键 词：急性胰腺炎 白蛋白 降钙素原 红细胞压积 

分 类 号：R576[医药卫生—消化系统]