血清CEA、AFP、CA125联合检测对卵巢肿瘤的鉴别诊断价值探讨  

Exploring the diagnostic value of combined detection of serum CEA,AFP and CA125 in ovarian tumor

作　　者：黄沉 沈舜钦 HUANG Chen;SHEN Shun-qin(Zhangzhou Zhengxing Hospital,Zhangzhou 363000,China)

机构地区：[1]漳州正兴医院,363000

出　　处：《中国现代药物应用》2024年第22期99-102,共4页Chinese Journal of Modern Drug Application

摘　　要：目的 观察血清癌胚抗原(CEA)、甲胎蛋白(AFP)、糖类抗原125(CA125)联合检测对卵巢肿瘤的诊断价值。方法 选取60例良性卵巢肿瘤患者作为良性组,同期60例恶性卵巢肿瘤患者作为恶性组,60例健康体检者作为健康组。检测三组血清CA125、AFP、CEA水平。比较三组血清CEA、AFP、CA125水平,并以病理诊断作为金标准,分析以上指标联合检测对卵巢肿瘤良恶性的鉴别诊断效能。结果 恶性组患者CEA(20.49±3.43)ng/ml、AFP(98.36±17.52)ng/ml、CA125(27.26±3.41)U/ml高于良性组的(5.58±0.76)ng/ml、(2.77±0.42)ng/ml、(4.57±1.52)U/ml和健康组的(2.15±0.52)ng/ml、(0.94±0.15)ng/ml、(2.73±0.55)U/ml,且良性组高于健康组,差异有统计学意义(P<0.05)。联合检测的敏感性为98.33%,特异性为96.67%,准确性为97.50%,阳性预测值为96.72%,阴性预测值为98.31%;CEA单一检测的敏感性为56.67%,特异性为65.00%,准确性为60.83%,阳性预测值为61.82%,阴性预测值为60.00%;AFP单一检测的敏感性为51.67%,特异性为70.00%,准确性为60.83%,阳性预测值为63.27%,阴性预测值为59.15%;CA125单一检测的敏感性为55.00%,特异性为73.33%,准确性为64.17%,阳性预测值为67.35%,阴性预测值为61.97%。联合检测的敏感性、特异性、准确性、阳性预测值、阴性预测值均高于血清CEA、AFP、CA125单一检测,差异有统计学意义(P<0.05)。结论 针对女性卵巢的健康检查,血清CEA、AFP、CA125联合检测方式对于卵巢肿瘤的良恶性有着很高的鉴别诊断价值,可为临床医生制定治疗措施提供参考依据。Objective To observe the diagnostic value of combined detection of serum carcinoembryonic antigen(CEA),alpha fetoprotein(AFP),and carbohydrate antigen 125(CA125) in ovarian tumor.Methods 60 patients with benign ovarian tumors were selected as the benign group,60 patients with malignant ovarian tumors as the malignant group,and 60 healthy individuals as the healthy group.The serum levels of CA125,AFP and CEA among the three groups were detected.The differences in serum levels of CEA,AFP,and CA125 were compared among three groups,and the efficiency of the combined detection of the above indexes in differential diagnosis of benign and malignant ovarian tumors was analyzed with pathological diagnosis as the gold standard.Results The tumor group had CEA of(20.49±3.43) ng/ml,AFP of(98.36±17.52) ng/ml and CA125 of(27.26±3.41) U/ml,which were higher than(5.58±0.76) ng/ml,(2.77±0.42) ng/ml and(4.57±1.52) U/ml in the benign group,and(2.15±0.52) ng/ml,(0.94±0.15) ng/ml and(2.73±0.55) U/ml in the healthy group;the benign group was higher than the healthy group;the difference was statistically significant(P<0.05).The sensitivity of the combined detection was 98.33%,the specificity was 96.67%,the accuracy was 97.50%,the positive predictive value was 96.72%,and the negative predictive value was 98.31%;the sensitivity of CEA single detection was 56.67%,the specificity was 65.00%,the accuracy was 60.83%,the positive predictive value was 61.82%,and the negative predictive value was 60.00%;the sensitivity of AFP single detection was 51.67%,the specificity was 70.00%,the accuracy was 60.83%,the positive predictive value was 63.27%,and the negative predictive value was 59.15%;the sensitivity of CA125 single detection was 55.00%,the specificity was 73.33%,the accuracy was 64.17%,the positive predictive value was 67.35%,and the negative predictive value was 61.97%.The sensitivity,specificity,accuracy,positive predictive value,and negative predictive value of combined detection were all higher than those of single detection of

关 键 词：血清癌胚抗原 甲胎蛋白 糖类抗原125 联合检测 卵巢肿瘤 诊断价值 

分 类 号：R737.31[医药卫生—肿瘤]