雌激素及其受体β在结直肠癌中的研究进展  

Research Progress of Estrogen and its Receptorβin Colorectal Cancer

作　　者：李义 魏志 Li Yi;Wei Zhi(Gastroen Terology Department,Shandong Second Provincial General Hospital,Jinan,Shandong,250000,China)

机构地区：[1]山东省第二人民医院消化科,山东济南250000

出　　处：《黑龙江医学》2024年第23期2933-2935,共3页Heilongjiang Medical Journal

基　　金：山东省医药卫生科技发展计划项目(202003030952)。

摘　　要：雌激素是一种类固醇激素,除调节生殖功能外,还可以调节靶组织中的多种细胞过程,如信号转导和转录过程。雌激素通过雌激素受体(ER)激活信号通路,通过基因组和非基因组反应来调控基因表达而发挥作用。研究发现雌激素能降低女性结直肠癌(CRC)发病率,尤其是ERβ的表达被认为在其中发挥保护作用。总结了雌激素及其受体在CRC中的相关研究,并详细阐述了ERβ在CRC发病中的潜在机制。Estrogen is a steroid hormone,which can regulate various cellular processes in target tissues,such as signal transduction and transcription,except for regulating reproductive function.Estrogen activates signaling pathways through estrogen receptor(ER),regulating gene expression through both genomic and non-genomic responses.Studies have found that estrogen can reduce the incidence rate of colorectal cancer(CRC)in women,especially ERβis believed to play a protective role.The relevant research on estrogen and its receptors in CRC is summarized,and the potential mechanisms on ERβin the pathogenesis of CRC elaborated.

关 键 词：雌激素 雌激素受体Β 结直肠癌 发病机制 

分 类 号：R735.3[医药卫生—肿瘤]