术前外周血炎症标志物联合HE4在浆液性卵巢癌诊断中的价值  

Value of Preoperative Peripheral Blood Inflammatory Markers Combined with HE4 in the Diagnosis of Serous Ovarian Cancer

作　　者：李松磊[1,2] 张雯 荣守华 孟祥颖[1,2] 宋晓妍 袁恩武[1,2] LI Songlei;ZHANG Wen;RONG Shouhua;MENG Xiangying;SONG Xiaoyan;YUAN Enwu(Department of Laboratory Medicine,the Third Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China;Zhengzhou Key Laboratory for In Vitro Diagnosis of Hypertensive Disorders of Pregnancy,Zhengzhou 450052,China)

机构地区：[1]郑州大学第三附属医院检验医学科,河南郑州450052 [2]郑州市妊娠期高血压疾病体外诊断重点实验室,河南郑州450052

出　　处：《河南医学研究》2024年第23期4274-4278,共5页Henan Medical Research

摘　　要：目的探讨术前外周血炎症标志物血小板与淋巴细胞比值(PLR)、中性粒细胞与淋巴细胞比值(NLR)、单核细胞与淋巴细胞比值(MLR)联合人附睾蛋白4(HE4)对浆液性卵巢癌的诊断价值以及与临床病理特征的相关性。方法回顾性分析郑州大学第三附属医院2021年8月至2023年8月收治的92例浆液性卵巢癌患者为浆液性卵巢癌组,并选取同期收治的88例卵巢良性肿瘤患者为对照组,收集两组患者术前PLR、NLR、MLR和HE4水平的实验室资料以及浆液性卵巢癌组患者术后病理资料。比较两组患者术前PLR、NLR、MLR和HE4的表达差异,应用受试者工作特征(ROC)曲线评估PLR、NLR、MLR联合HE4对浆液性卵巢癌的诊断价值,并分析PLR、NLR、MLR与临床病理特征的关系。结果与对照组相比,PLR、NLR、MLR和HE4水平在浆液性卵巢癌组中较高(P<0.05);PLR、NLR、MLR、HE4以及四者联合检测对浆液性卵巢癌诊断的ROC曲线下面积分别为0.693、0.733、0.759、0.937、0.954,灵敏度分别为72.8%、70.7%、84.8%、79.3%、80.4%,特异度分别为61.2%、69.4%、52.9%、96.5%、95.3%。PLR与FIGO分期有关,NLR与FIGO分期和淋巴结转移有关,MLR与FIGO分期和组织分化有关。结论术前NLR、PLR和MLR与浆液性卵巢癌的病理分期、组织分化和淋巴结转移密切相关,术前外周血炎症标志物与HE4联合检测可以作为浆液性卵巢癌诊断中的重要参考指标,可为临床诊治提供参考信息。Objective To explore the diagnostic value of preoperative peripheral blood inflammatory markers such as platelet to lymphocyte ratio(PLR),neutrophil to lymphocyte ratio(NLR),monocyte to lymphocyte ratio(MLR)combined with human epididymal protein 4(HE4)for serous ovarian cancer(SOC)and their correlation with clinical and pathological features.Methods A retrospective analysis was conducted on 92 patients with SOC admitted to the Third Affiliated Hospital of Zhengzhou University from August 2021 to August 2023 as the SOC group,and 88 patients with benign ovarian tumors during the same period were selected as the control group.Laboratory data on preoperative PLR,NLR,MLR,and HE4 levels,as well as postoperative pathological data of patients in the SOC group,were collected from both groups.The expression differences of PLR,NLR,MLR,and HE4 were compared between two groups of patients before surgery,the diagnostic value of PLR,NLR,MLR combined with HE4 for SOC were evaluated using receiver operating(ROC)curve,and the relationship was analyzed between PLR,NLR,MLR and clinical pathological features.Results Compared with the control group,the levels of PLR,NLR,MLR,and HE4 were increased in the SOC group,and the difference was statistically significant(P<0.05).The area under the ROC curve of PLR,NLR,MLR,HE4,and the above four combined detection for the diagnosis of SOC were 0.693,0.733,0.759,0.937,and 0.954,respectively,with sensitivities of 72.8%,70.7%,84.8%,79.3%,and 80.4%,and specificity of 61.2%,69.4%,52.9%,96.5%,and 95.3%,respectively.PLR was related to FIGO staging,NLR was related to FIGO staging and lymph node metastasis,and MLR was related to FIGO staging and tissue differentiation.Conclusion Preoperative NLR,PLR,and MLR are closely related to the pathological staging,tissue differentiation,and lymph node metastasis of serous ovarian cancer.Preoperative peripheral blood inflammatory markers combined with HE4 detection can serve as important reference indicators in the diagnosis of SOC and provide reference information

关 键 词：浆液性卵巢癌 血小板与淋巴细胞比值 中性粒细胞与淋巴细胞比值 单核细胞与淋巴细胞比值 病理特征 

分 类 号：R36[医药卫生—病理学]