血清sTNFR1、5-HT、miR-146a-5p水平对首发精神分裂症患者的诊断价值  

Diagnostic Value of Serum Levels of sTNFR1, 5-HT, and miR-146a-5p in Patients with First-Episode Schizophrenia

作　　者：刘杰 LIU Jie(Department of Psychiatry,Shangqiu Second People’s Hospital,Shangqiu 476002,China)

机构地区：[1]商丘市第二人民医院精神科,河南商丘476000

出　　处：《河南医学研究》2024年第23期4336-4340,共5页Henan Medical Research

摘　　要：目的探讨血清可溶性肿瘤坏死因子受体1(sTNFR1)、5-羟色胺(5-HT)、miR-146a-5p水平对首发精神分裂症患者的诊断价值。方法选取2020年6月至2022年6月商丘市第二人民医院收治的128例首发精神分裂症患者作为病例组,另选135例同期收治的健康体检者作为对照组。病例组患者均接受奥氮平片治疗,均持续治疗1个月。收集两组的临床资料,比较血清sTNFR1、5-HT、miR-146a-5p水平,用Pearson相关性分析首发精神分裂症患者血清sTNFR1、5-HT、miR-146a-5p水平与阳性与阴性症状量表(PANSS)评分的相关性,绘制受试者工作特征(ROC)曲线,分析血清sTNFR1、5-HT、miR-146a-5p对首发精神分裂症的诊断价值。结果病例组PANSS评分及sTNFR1水平高于对照组(P<0.05),5-HT、miR-146a-5p水平低于对照组(P<0.05)。与治疗前比较,病例组治疗1个月后sTNFR1水平降低(P<0.05);5-HT、miR-146a-5p水平升高(P<0.05)。Pearson相关性分析结果显示,首发精神分裂症患者sTNFR1水平与PANSS评分呈正相关(r=0.623,P<0.05);5-HT、miR-146a-5p水平与PANSS评分呈负相关(r=-0.498、-0.521,P<0.05)。sTNFR1、5-HT、miR-146a-5p联合检测诊断首发精神分裂症的曲线下面积(AUC)为0.915,高于sTNFR1、5-HT、miR-146a-5p单独检测(P<0.05)。结论首发精神分裂症患者sTNFR1水平呈高表达,5-HT、miR-146a-5p水平呈低表达,经治疗后三者水平同步改善,且三者水平变化参与首发精神分裂症的发生发展过程,另三者联合检测对首发精神分裂症的诊断价值更高。Objective To investigate the diagnostic value of serum levels of soluble tumor necrosis factor receptor 1(sTNFR1),5-hyd roxytryptamine(5-HT),and microribonucleic acid-146a-5p(miR-146a-5p)in patients with first-episode schizophrenia.Methods A total of 128 patients with first-episode schizophrenia admitted to the Second People’s Hospital of Shangqiu from June 2020 to June 2022 were selected as the case group,and another 135 healthy individuals admitted during the same period were selected as the control group.All patients in the case group received treatment with olanzapine tablets and continued for 1 month.The clinical data from two groups were collected,the serum levels of sTNFR1,5-HT,and miR-146a-5p between the two groups and before and after 1 month of treatment of the case group were compared.The correlation between serum levels of sTNFR1,5-HT,miR-146a-5p and score of PANSS in first-episode schizophrenia patients was using Pearson correlation analysis,draw subject operating characteristic(ROC)curves,and the diagnostic value of serum levels of sTNFR1,5-HT,and miR-146a-5p in first-episode schizophrenia was analyzed.Results The score of positive and negative symptom scale(PANSS)and serum level of sTNFR1 in the case group were higher than the control group(P<0.05),the serum levels of 5-HT and miR-146a-5p were lower than the control group(P<0.05).Compared with before treatment,the serum level of sTNFR1 in the case group decreased after 1 month of treatment(P<0.05),the serum levels of 5-HT and miR-146a-5p increased(P<0.05).The Pearson correlation analysis results showed that the serum sTNFR1 level in first-episode schizophrenia patients was positively correlated with score of PANSS(r=0.623,P<0.05),the levels of serum 5-HT and miR-146a-5p were negatively correlated with score of PANSS(r=-0.498,-0.521,P<0.05).The area under the curve(AUC)value of the combined detection of serum sTNFR1,5-HT,and miR-146a-5p for the diagnosis of first-episode schizophrenia was 0.915,which was higher than that of the individual detectio

关 键 词：精神分裂症 首发 可溶性肿瘤坏死因子受体1 5-羟色胺 miR-146a-5p 诊断价值 

分 类 号：R741[医药卫生—神经病学与精神病学]