血清IL-10、VEGF水平与宫颈癌患者术后预后的关系  

Relationship Between Serum IL-10, VEGF Levels and Prognosis of Patients with Uterine Cervical Carcinoma After Surgical

作　　者：刘燕 刘红威 LIU Yan;LIU Hongwei(Department of Obstetrics and Gynecology,Zhumadian Maternal and Child Health Hospital of Henan Province,Zhumadian 463000,China;Department of Anesthesiology,the First People’s Hospital of Zhumadian,Zhumadian 463000,China)

机构地区：[1]驻马店市妇幼保健院妇产科,河南驻马店463000 [2]驻马店市第一人民医院麻醉科,河南驻马店463000

出　　处：《河南医学研究》2024年第23期4344-4347,共4页Henan Medical Research

摘　　要：目的观察血清白细胞介素-10(IL-10)、血管内皮生长因子(VEGF)水平与宫颈癌(UCC)患者手术治疗预后的相关性。方法前瞻性选择2018年6月至2019年6月驻马店市妇幼保健院收治的126例UCC患者为研究对象,所有患者入院时均接受血清IL-10、VEGF水平检测,并行改良根治性子宫切除术治疗,术后进行2 a随访,记录患者随访期间是否复发,将复发的患者纳入预后不良组,其他未复发患者纳入预后良好组,询问并记录患者一般资料,分析IL-10、VEGF水平与手术预后的关系。结果126例患者均获得2 a随访,随访期间复发26例,复发率为20.63%(26/126)。预后不良组临床分期中Ⅱ期占比、腺癌占比高于预后良好组,入院时血清IL-10、VEGF水平较预后良好组高(P<0.05)。logistic回归分析结果显示,UCC患者入院时血清IL-10、VEGF过表达、病理分型为腺癌、临床分期高与手术后预后有关,可能是预后不良风险因子(OR>1,P<0.05)。血清IL-10、VEGF水平单独及联合预测UCC患者手术治疗预后AUC分别为0.764、0.757、0.816,均>0.70,预测价值较高。结论血清IL-10、VEGF过表达与UCC患者手术治疗预后不良有关,临床可通过入院时血清IL-10、VEGF水平预测UCC患者手术治疗预后不良发生风险。Objective To observe the correlation between the levels of serum interleukin-10(IL-10),vascular endothelial growth factor(VEGF)and the prognosis of patients with uterine cervical carcinoma(UCC)after surgical treatment.Methods A total of 126 patients with UCC treated in Zhumadian Maternal and Child Health Hospital from June 2018 to June 2019 were prospectively selected as the research subjects,and all patients underwent serum IL-10 and VEGF levels testing upon admission and underwent modified radical hysterectomy treatment.They were followed up for 2 years to observe the recurrence during the follow-up period.The recurrence of the patients was taken as a prognostic indicator and grouped into groups.Recurrent patients were included in the group with poor prognosis,while non recurrent patients were included in the group with good prognosis.The general data of patients were asked and recorded,and the relationship between serum IL-10 and VEGF levels and the prognosis of UCC patients after surgical treatment was analyzed.Results All 126 patients were followed up for 2 years,with 26 cases experiencing recurrence during the follow-up period,with a recurrence rate of 20.63%(26/126).The proportion of stageⅡand adenocarcinoma in the clinical staging of the poor prognosis group was higher than that of the good prognosis group.The serum IL-10 and VEGF levels at admission were higher than those of the good prognosis group(P<0.05).The results of logistic regression analysis showed that the overexpression of serum IL-10 and VEGF at admission,pathological classification as adenocarcinoma,and high clinical staging of UCC patients were associated with postoperative prognosis,and might be risk factors for poor prognosis(OR>1,P<0.05).The serum IL-10 and VEGF levels alone and in combination predict the AUC of surgical treatment prognosis in UCC patients,which were 0.764,0.757,and 0.816,respectively,with values greater than 0.70,indicating high predictive value.Conclusion Overexpression of serum IL-10 and VEGF is associated with poor

关 键 词：宫颈癌 根治性子宫切除术 白细胞介素-10 血管内皮生长因子 预后 

分 类 号：R737.3[医药卫生—肿瘤]