脑栓死患者血清sCD40L、FGF23、Hcy、hs-CRP水平及其与颈动脉斑块的关系  

Changes of Levels of Serum sCD40L, FGF23, Hcy, hs-CRP and Their Relationship with Carotid Artery Plaque in Patients with Cerebral Embolism

作　　者：卢才磊 LU Cailei(Department of Neurology,Anyang Third People’s Hospital,Anyang 455000,China)

机构地区：[1]安阳市第三人民医院神经内科,河南安阳455000

出　　处：《河南医学研究》2024年第23期4348-4351,共4页Henan Medical Research

摘　　要：目的探讨脑栓死患者血清可溶性CD40配体(sCD40L)、成纤维细胞生长因子23(FGF23)、同型半胱氨酸(Hcy)、超敏C反应蛋白(hs-CRP)水平变化及与颈动脉斑块的关系。方法以2021年1月至2022年12月安阳市第三人民医院收治的合并颈动脉斑块的110例脑栓死患者作为脑栓死组,选取同期在医院进行体检的119例健康体检者作为对照组,统计两组一般资料,比较两组血清sCD40L、FGF23、Hcy、hs-CRP水平、颈动脉超声检查结果及脑栓死不同颈动脉斑块稳定性患者血清sCD40L、FGF23、Hcy、hs-CRP水平,采用Pearson相关分析血清sCD40L、FGF23、Hcy、hs-CRP水平与脑栓死患者颈动脉斑块的相关性。结果脑栓死组血清sCD40L、FGF23、Hcy、hs-CRP水平及颈动脉斑块数量、斑块评分、颈动脉内膜中层厚度(IMT)高于对照组(P<0.05)。斑块不稳定组血清sCD40L、FGF23、Hcy、hs-CRP水平高于斑块稳定组(P<0.05)。Pearson相关分析结果显示,血清sCD40L、FGF23、Hcy、hs-CRP与脑栓死患者颈动脉斑块数量、斑块评分、IMT均呈正相关(r>0,P<0.05)。结论血清sCD40L、FGF23、Hcy、hs-CRP与脑栓死的发生和颈动脉斑块情况密切相关,可用于不稳定斑块的诊断,对于脑栓死发生的预测具有积极意义。Objective To investigate the changes of levels of serum soluble CD40 ligand(sCD40L),fibroblast growth factor 23(FGF23),homocysteamine(Hcy),hypersensitive C-reactive protein(hs-CRP)in patients with cerebral embolism and their relationship with carotid artery plaque.Methods A total of 110 cases of cerebral embolism patients with carotid artery plaque admitted to Anyang Third People’s Hospital from January 2021 to December 2022 were selected as the cerebral embolism group,119 cases of healthy physical examination subjects who underwent physical examination in hospital during the same period were selected as the control group,and the general data of the two groups were analyzed.Levels of serum sCD40L,FGF23,Hcy,hs-CRP,carotid ultrasound results and levels of serum sCD40L,FGF23,Hcy,hs-CRP in patients with cerebral embolism with different carotid plaque stability were compared between the two groups.Pearson correlation was used to analyze the correlation between serum levels of sCD40L,FGF23,Hcy,hs-CRP and carotid artery plaque in patients with cerebral embolism.Results The serum levels of sCD40L,FGF23,Hcy,hs-CRP,carotid artery plaque number,plaque evaluation and carotid intima-media thickness(IMT)in the cerebral embolism group were higher than those in the control group(P<0.05).The clear levels of sCD40L,FGF23,Hcy and hs-CRP in the plaque unstable group were higher than those in the plaque stable group(P<0.05).Pearson correlation analysis showed that serum sCD40L,FGF23,Hcy and hs-CRP were significantly positively correlated with carotid plaque number,score of plaque and IMT in patients with cerebral embolism(r>0,P<0.05).Conclusion Serum sCD40L,FGF23,Hcy,hs-CRP were closely related to the occurrence of cerebral embolism and carotid artery plaque,and could be used for the diagnosis of unstable plaque,which had positive significance for the prediction of the occurrence of cerebral embolism.

关 键 词：脑栓死 可溶性CD40配体 成纤维细胞生长因子23 同型半胱氨酸 超敏C反应蛋白 颈动脉斑块 

分 类 号：R741[医药卫生—神经病学与精神病学]