地佐辛联合布托啡诺对宫颈癌根治术患者术后镇痛效果和免疫功能的影响  

Effects of Dezocine Combined with Butorphanol on Postoperative Analgesia Effect and Immune Function in Patients Undergoing Radical Hysterectomy for Cervix Carcinoma

作　　者：周勇[1] 刘喆[1] 刘远征 ZHOU Yong;LIU Zhe;LIU Yuan-zheng(Department of Anesthesiology,Nanyang Central Hospital,Nanyang 473000,China)

机构地区：[1]南阳市中心医院麻醉科,南阳473000

出　　处：《中国合理用药探索》2024年第11期108-112,共5页Chinese Journal of Rational Drug Use

基　　金：河南省医学科技攻关计划项目(LHGJ20210537)。

摘　　要：目的:探讨地佐辛联合布托啡诺对宫颈癌根治术患者术后镇痛效果和免疫功能的影响。方法:选取2019年10月~2021年10月某院接收的122例行宫颈癌根治术的患者作为研究对象,采用随机数字表法分为对照组和观察组,每组61例。两组患者均进行宫颈癌外科手术,麻醉诱导相同。对照组患者给予布托啡诺麻醉,观察组患者给予地佐辛联合布托啡诺麻醉。比较两组患者镇痛效果[视觉模拟评分(VAS)]、疼痛应激因子[β-内啡肽(β-EP)、神经肽Y(NPY)、P物质(SP)]、免疫功能[CD3^(+)、CD4^(+)、CD8^(+)、自然杀伤(NK)细胞]以及不良反应发生情况。结果:术后4h、8h和12h,两组患者VAS评分逐渐降低,且观察组低于对照组(P<0.05)。术后12h,两组患者β-EP、NPY和SP水平均升高,但观察组低于对照组(P<0.05)。术后12h,两组患者CD3^(+)、CD4^(+)和NK细胞^(+)水平均降低,但观察组高于对照组;CD8水平升高,但观察组低于对照组(P<0.05)。术后12h,观察组患者不良反应总发生率低于对照组(P<0.05)。结论:地佐辛联合布托啡诺能减轻宫颈癌根治术患者术后的疼痛,调节患者机体免疫功能,且能减少术后不良反应的发生。Objective:To investigate the effects of dezocine combined with butorphanol on postoperative analgesia effect and immune function in patients undergoing radical hysterectomy for cervix carcinoma.Methods:A total of 122 patients undergoing radical hysterectomy for cervix carcinoma in a hospital from October 2019 to October 2021 were selected and assigned to the control group and observation group by random number table,with 61 patients in each group.Both groups of patients underwent cervical cancer surgery with the same anesthesia induction.The control group was given butorphanol for anesthesia,while the observation group was given dezocine combined with butorphanol for anesthesia.The analgesic effect[visual analogue scale(VAS)],pain stress factors[β-endorphin(β-EP),neuropeptide Y(NPY),substance P(SP)],immune function[CD3^(+),CD4^(+),CD8^(+),natural killer(NK)cells]and adverse reactions were compared between the two groups.Results:At 4,8,12h after operation,the VAS scores were gradually decreased in the two groups,with the observation group showing lower scores than the control group(P<0.05).At 12h after operation,the levels ofβ-EP,NPY and SP were increased in the two groups,with the observation group showing lower levels than the control group(P<0.05).At 12h after operation,the levels of CD3^(+),CD4^(+)and NK cells were decreased in the two groups,but the observation group was higher than the control group;CD8^(+)levels were increased,but the observation group was lower than the control group(P<0.05).At 12h after operation,the total incidence of adverse reactions in the observation group was lower than that in the control group(P<0.05).Conclusion:Dezocine combined with butorphanol can relieve postoperative pain in patients undergoing radical hysterectomy for cervix carcinoma,regulate the immune function and reduce the incidence of postoperative adverse reactions.

关 键 词：地佐辛 布托啡诺 宫颈癌根治术 镇痛效果 免疫功能 

分 类 号：R737.33[医药卫生—肿瘤] R614[医药卫生—临床医学]