血清LDL、ApoA-1水平与广泛期小细胞肺癌患者无进展生存期的关系  

Relationship between serum LDL and ApoA-1 levels and progression free survival in patients with extensive small cell lung cancer

作　　者：邢丹 刘婉玉 陈露 XING Dan;LIU Wanyu;CHEN Lu(Department of Medical Laboratory,Zhumadian Central Hospital,Zhumadian,Henan 463000,China)

机构地区：[1]驻马店市中心医院医学检验科,河南驻马店463000

出　　处：《现代医药卫生》2024年第23期4017-4022,共6页Journal of Modern Medicine & Health

基　　金：河南省医学科技攻关计划(联合共建)项目(LHGJ20210730)。

摘　　要：目的探讨血清低密度脂蛋白(LDL)、载脂蛋白A-1(ApoA-1)与广泛期小细胞肺癌患者无进展生存期的关系。方法收集2020年3月至2023年3月该院收治的145例广泛期小细胞肺癌患者的临床资料(观察组),观察组患者均完成6个周期化疗及1年随访。另收集同期于该院进行体检且与观察组性别、年龄、体重指数相匹配的145例健康人群体检资料(对照组),比较2组研究对象血清LDL、ApoA-1检测结果,比较观察组患者治疗期间不同时间点血清LDL、ApoA-1水平,并收集观察组患者随访期间无进展生存期及预后情况,采用Spearman相关分析血清LDL、ApoA-1水平与广泛期小细胞肺癌患者无进展生存期的相关性,采用Cox回归模型分析广泛期小细胞肺癌患者预后不良的影响因素。结果观察组患者血清LDL水平高于对照组,血清ApoA-1水平低于对照组,差异有统计学意义(P<0.05);治疗6个周期时血清LDL水平均较入院时、治疗3个周期时升高,血清ApoA-1水平均较入院时、治疗3个周期时降低,差异有统计学意义(P<0.05);145例广泛期小细胞肺癌患者无进展生存期为4~16个月,中位生存时间7.1个月,预后不良103例,预后良好42例;经Spearman相关分析显示,血清LDL水平与广泛期小细胞肺癌无进展生存期呈负相关(r=-0.617,P<0.001),血清ApoA-1水平与广泛期小细胞肺癌无进展生存期呈正相关(r=0.509,P<0.001);预后不良组患者血清神经元特异性烯醇化酶、癌胚抗原、细胞角蛋白19片段抗原、LDL水平高于预后良好组,ApoA-1水平低于预后良好组,差异有统计学意义(P<0.05);经Cox回归分析显示,血清神经元特异性烯醇化酶、癌胚抗原、细胞角蛋白19片段抗原、入院时血清LDL、入院时血清ApoA-1水平均是广泛期小细胞肺癌预后不良的影响因素(P<0.05)。结论血清LDL水平与广泛期小细胞肺癌无进展生存期呈负相关,血清ApoA-1水平与广泛期小细胞肺癌无进展生存期�Objective To investigate the relationship between serum low density lipoprotein(LDL),apolipoprotein A-1(ApoA-1)and progression free survival in patients with extensive small cell lung cancer.Methods The clinical data of 145 patients with extensive-stage small cell lung cancer(observation group)admitted to our hospital from March 2020 to March 2023 were collected.Patients in the observation group completed six cycles of chemotherapy and were followed up for one year.Additionally,the physical examination data of 145 healthy individuals who underwent physical examinations at the same hospital during the same period and matched the observation group in terms of gender,age,and body mass index were collected(control group).The serum levels of LDL and ApoA-1 were compared between the two groups.The serum levels of LDL and ApoA-1 at different time points during treatment in the observation group were also compared.The progression free survival and prognosis of patients in the observation group during the follow-up period were collected.Spearman correlation analysis was used to assess the correlation between serum LDL,ApoA-1 levels,and progression free survival in patients with extensive-stage small cell lung cancer.Cox regression analysis was conducted to identify the factors influencing poor prognosis in patients with extensive-stage small cell lung cancer.Results The serum LDL level in observation group was higher than that in control group,and the serum ApoA-1 level was lower than that in control group,with statistical significant differences(P<0.05).The serum LDL levels at 6 treatment cycles were higher than those at admission and 3 treatment cycles,and the serum ApoA-1 levels were lower than those at admission and 3 treatment cycles,with statistical significant differences(P<0.05).The progression free survival of 145 patients with extensive stage small cell lung cancer was 4-16 months,the median survival time was 7.1 months,103 cases had poor prognosis and 42 cases had good prognosis.Through Spearman correlation ana

关 键 词：广泛期小细胞肺癌 无进展生存期 低密度脂蛋白 载脂蛋白A-1 相关性 

分 类 号：R734.2[医药卫生—肿瘤]