Emerging Sialylated Class R Lipooligosaccharides in Campylobacter jejuni from Seagulls Has the Potential to Trigger Guillain-BarréSyndrome—Yunnan Province,China,2018–2023  

作　　者：Xiaoli Chen Yixin Gu Hairui Wang Guilan Zhou Xin Zhang Chang Liu Zhujun Shao Jianzhong Zhang Maojun Zhang 

机构地区：[1]National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases,National Institute for Communicable Disease Control and Prevention,Chinese Center for Disease Control and Prevention,Beijing,China

出　　处：《China CDC weekly》2024年第45期1177-1182,共6页中国疾病预防控制中心周报（英文）

基　　金：Supported by National Key Research and Development Program of China(2021YFC2301000);Research on detection and tracing of important pathogen combinations,identification and prevention of drug resistance hazards(SZSM201803081);Project for Gonorrhea vaccine development(2023110024000074).

摘　　要：What is already known about this topic?Lipooligosaccharides from Campylobacter jejuni(C.jejuni)have a mimicry antigen structure with gangliosides,which explains the mechanism by which C.jejuni caused Guillain-Barrésyndrome(GBS).What is added by this report?All 12 C.jejuni strains with class R LOSs and specific serotypes were isolated from seagulls in south China.These emerging C.jejuni strains had gangliosidemimicry antigen structures and possessed a high potential for triggering GBS.What are the implications for public health practice?Sialylated lipooligosaccharides(LOS)class R with GBS-associated serotypes isolated from seagulls highlight the risk of induced GBS around coastal or lakeside areas.

关 键 词：COASTAL OLIGOSACCHARIDES LIPO 

分 类 号：R378[医药卫生—病原生物学]