supported by the National Key Research and Development Program of China(2021YFA1301900 to H.D.);the National Natural Science Foundation of China(31900039 and 32170029 to X.T.,32000844 to S.C.,81971974 and 82372297 to H.D.);the 1.3.5 Project for Disciplines Excellence of West China Hospital,Sichuan University(ZYYC23014 to H.D.);the Sichuan Provincial Natural Science Foundation Outstanding Young Scientist Fund Project(2024NSFJQ0002 to H.D.).
Outer membrane(OM)lipoproteins serve vital roles in Gram-negative bacteria,contributing to their pathogenicity and drug resistance.For these lipoproteins to function,they must be transported from the inner membrane(IM...
Supported by National Key Research and Development Program of China(2021YFC2301000);Research on detection and tracing of important pathogen combinations,identification and prevention of drug resistance hazards(SZSM201803081);Project for Gonorrhea vaccine development(2023110024000074).
What is already known about this topic?Lipooligosaccharides from Campylobacter jejuni(C.jejuni)have a mimicry antigen structure with gangliosides,which explains the mechanism by which C.jejuni caused Guillain-Barrésy...
supported by grants from the National Natural Science Foundation of China(92057202 and 31871194);the National Key R&D Program of China(2018YFA0506900 and 2018YFA0800901).
Interorgan lipid transport is crucial for organism development and the maintenance of physiological function.Here,we demonstrate that Drosophila long-chain acyl-CoA synthetase(dAcsl),which catalyzes the conversion of ...
funded by Beijing Natural Science Foundation (Nos.L222109, 3222018);Military Health Care Project(No.22BJZ22);Science Foundation of China University of Petroleum (Nos.2462019QNXZ02, 2462019BJRC007);National Natural Science Foundation of China (Nos.52211530034, 82273236);Guangdong Provincial Basic and Applied Basic Research Foundation (Nos.2022A151522004, 2022A1515220042);Science and Technology Innovation Commission of Shenzhen (Nos.JSGG20210802153410031, JCYJ20220530141609021);Science and Technology Plan of Shenzhen Nanshan District (No.NS016);Discipline Leader Foundation of Huazhong University of Science and Technology Union Shenzhen Hospital (No.YN2021002);Crosswise Project of Daan Gene (No.HXKY2022002)。
Liposomes are one of the significant classes of antitumor nanomaterials and the most successful nanomedicine drugs in clinical translation. However, it is difficult to accurately reveal liposome delivery modes and dru...
supported by the National Natural Science Foundation of China(grant nos.21977063,92053110,and 22177061);the National Key Research and Development Program of China(grant no.2018YFA0902000);the China Postdoctoral Science Foundation(grant no.2020M680090);the Qilu Youth Scholar Program of Shandong University,the Central Government Guide Local Science and Technology Development Funds(grant no.YDZX20203700002579);the Nonprofit Central Research Institute Fund of Chinese Academy of Medical Sciences(grant no.2021-RC350-002);the CAMS Innovation Fund for Medical Sciences(CIFMS)(grant no.2021-1-I2M-026).
Lipoteichoic acids(LTAs)are macroamphiphiles composed of alditol,lipid,phosphate,and carbohydrate units.Due to their inherent complexity,it is a severe challenge to access LTAs with structural integrity from natural s...
supported by the two National Natural Science Foundations of China(81872618 and 81573144).
Dietary omega-3 polyunsaturated fatty acids(ω-3 PUFAs)can be classifi ed into animal-and plant-derivedω-3 PUFAs.Patients with type 2 diabetes(T2DM)are frequently accompanied by dyslipidemia,which is closely related ...
supported by the Natural Science Foundation of Zhejiang Province(LZ22C170003);the Zhejiang Provincial Key R&D Program of China(2021C02008);the Fundamental Research Funds for the Central University(226-2022-00113),and the“Hundred Talents Program”funding from Zhejiang University to TZS.
Pork is one of the main meats consumed by people,and its nutritional value is closely related to human health.The lipid deposition and composition of pork not only affect the sensory quality but also determine the nut...
supported by the National Natural Science Foundation of China(82060141,81960141);Merit-based Funding for High-level Talent Innovation and Entrepreneurship in Guizhou Province[(2021)02];Science and Technology Top Talent Project of General Higher Education Institutions in Guizhou Province(Qianjiaohe KY[2021]032).
Previous studies have shown mitochondrial dysfunction in various acute kidney injuries and chronic kidney diseases.Lipoic acid exerts potent effects on oxidant stress and modulation of mitochondrial function in damage...
Autologous fat grafting is an important surgical technique in aesthetic and reconstructive procedures.Fat grafting for breast reconstruction is now an established procedure for adding volume and improving cutaneous pl...