Polyunsaturated Fatty Acid Concentrations and Risk of Pneumoconiosis:A Two-sample Mendelian Randomization Study  

作　　者：Junyi He Chenwei Zhang Yukai Zhang Jingfen Zhang Xuesen Su Peiyun He Wenhui Bao Haizhao Liu Xiao Yu Yiwei Shi 

机构地区：[1]NHC Key Laboratory of Pneumoconiosis,Shanxi Key Laboratory of Respiratory Diseases,Department of Pulmonary and Critical Care Medicine,MOE Key Laboratory of Coal Environmental Pathogenicity and Prevention,The First Hospital of Shanxi Medical University,Taiyuan 030000,Shanxi,China [2]First Clinical Medical College,Shanxi Medical University,Taiyuan 030000,Shanxi,China [3]People’s Hospital,Shuozhou 036000,Shanxi,China

出　　处：《Biomedical and Environmental Sciences》2024年第11期1328-1333,共6页生物医学与环境科学（英文版）

基　　金：the Central Guidance for Regional Science and Technology Development Projects(YDZJSX2024B010);Research project of Shanxi Provincial Health Commission(2023XG019).

摘　　要：Pneumoconiosis refers to a group of interstitial lung diseases that arise from the prolonged inhalation of occupational dust,resulting in chronic inflammation,immune dysregulation,and lung fibrosis[1].According to the 2019 Burden of Disease database,there are currently 3.1 million cases of pneumoconiosis worldwide,with developing countries such as China experiencing a particularly significant burden.The complex pathogenesis of pneumoconiosis,along with the irreversible nature of pulmonary fibrosis,has led to a scarcity of effective therapeutic options.While the aetiology of pneumoconiosis is well established,additional factors,including diet,genetic susceptibility,and lifestyle habits,may influence an individual’s risk of developing the disease or its progression.Notably,moderate intake of polyunsaturated fatty acids(PUFAs)has been associated with a reduced risk of chronic respiratory diseases and the modulation of lung inflammation through the regulation of antioxidant signaling pathways[2].However,the potential impact of PUFAs on pneumoconiosis remains an area requiring further investigation.

关 键 词：INFLAMMATION LUNG INTAKE 

分 类 号：R135.2[医药卫生—劳动卫生]