脊髓损伤后肠道菌群变化及其对脊髓神经炎症影响的研究进展  

Research progress in changes of intestinal flora after spinal cord injury and their effects on spinal neuroinflammation

作　　者：陈海霞 李泓儒 刘婧怡 徐枝芳 刘淑文 杨媛 陈阳 骆雨 崔银洁 CHEN Haixia;LI Hongru;LIU Jingyi;XU Zhifang;LIU Shuwen;YANG Yuan;CHEN Yang;LUO Yu;CUI Yinjie(Experimental Acupuncture Research Center,School of Acupuncture,Moxibustion and Tuina,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;National Clinical Research Center for Acupuncture and Moxibustion of Traditional Chinese Medicine,Affiliated Hospital,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;School of Traditional Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;School of Medical Technology,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China)

机构地区：[1]天津中医药大学针灸推拿学院实验针灸学研究中心,天津301617 [2]天津中医药大学第一附属医院国家中医针灸临床医学研究中心,天津300193 [3]天津中医药大学中医学院,天津301617 [4]天津中医药大学医学技术学院,天津301617

出　　处：《吉林大学学报（医学版）》2024年第6期1751-1756,共6页Journal of Jilin University：Medicine Edition

基　　金：国家自然科学基金项目(82105019)。

摘　　要：肠道菌群是一个巨大的微生物生态系统,特异性地存在于机体,并与其代谢产物共同对机体的健康或疾病状态起重要调节作用。脊髓损伤后,创伤局部复杂的病理生理导致轴突再生困难,脊髓损伤诱导的自主神经运动功能障碍破坏胃肠道功能并引起肠道菌群紊乱。既往脊髓损伤后神经修复策略的临床疗效并不理想。紊乱的肠道菌群和脊髓损伤后神经炎症与患者预后有密切关联。肠道菌群对脊髓损伤后神经炎症的潜在作用机制可能包括失衡菌群激活肠道相关淋巴组织并破坏肠道屏障,肠道菌群及其代谢产物脂多糖(LPS)、短链脂肪酸(SCFAs)、5-羟色胺(5-HT)和色氨酸等及免疫细胞、炎症因子和神经递质通过循环系统影响脊髓局部炎症反应。现对脊髓损伤后肠道菌群变化及其对脊髓神经炎症影响的研究进行综述,为探索脊髓损伤后神经炎症改善提供新靶点和新思路。The gut microbiota is a vast microbial ecosystem,specifically present in the organism and plays an important regulatory role in the body’s health or disease state together with its metabolites.After spinal cord injury,the complex pathophysiology at the site of trauma makes axonal regeneration difficult,and the autonomic motor dysfunction induced by spinal cord injury disrupts gastrointestinal function and causes gut microbiota imbalance.The previous clinical outcomes of neurorepair strategies after spinal cord injury have not been ideal.The dysregulated gut microbiota and neuroinflammation after spinal cord injury are closely associated with the prognosis of the patients. The potential mechanisms by which the gut microbiota may influence the neuroinflammation after spinal cord injury may include the activation of gut-associated lymphoid tissue and disruption of the intestinal barrier by the imbalanced microbiota, and gut microbiota and its metabolites such as lipopolysaccharides(LPS), short chain fatty acids(SCFAs), 5-hydroxytryptamine(5-HT), and tryptophan, as well as immune cells, inflammatory factors, and neurotransmitters the local inflammatory response in the spinal cord through the circulatory system. This paper revews the studies on the changes in gut microbiota after spinal cord injury and their effects on the spinal cord neuroinflammation, providing new targets and new ideas for improving the neuroinflammation after spinal cord injury.

关 键 词：脊髓损伤 神经炎症 肠道菌群 代谢 

分 类 号：R744[医药卫生—神经病学与精神病学]