神经生长因子辅助治疗对帕金森病患者运动功能的影响  

Effect of Nerve Growth Factor Adjuvant Therapy on Motor Function in Patients with Parkinson's Disease

作　　者：焦丽梅[1] JIAO Li-mei(Second Department of Neurology,The Fourth Hospital of Handan City,Handan,Hebei 056200,China)

机构地区：[1]河北省邯郸市第四医院神内二科,河北邯郸056200

出　　处：《河北北方学院学报（自然科学版）》2024年第11期8-10,共3页Journal of Hebei North University:Natural Science Edition

摘　　要：目的探讨神经生长因子辅助治疗对帕金森病患者运动功能的影响。方法120例帕金森病患者按随机数字表法分为对照组与观察组各60例。对照组给予口服多巴丝肼和卡比多巴等常规药物治疗,观察组在对照组治疗基础上给予神经生长因子辅助治疗。治疗3周后,应用平衡仪、Berg平衡量表和“起立-行走”计时测试评估患者运动功能改善情况。结果治疗前,2组患者平均重心移动范围、平均Berg平衡量表评分、平均“起立-行走”时间组间差异无统计学意义(P>0.05);治疗后均较治疗前改善,观察组改善优于对照组(P<0.05)。结论神经生长因子辅助治疗帕金森病可明显改善患者运动功能,值得临床参考应用。Objective To investigate the effect of nerve growth factor on motor function in patients with Parkinson's disease.Methods A total of 120 patients with Parkinson's disease were divided into control group and observation group according to random number table method,with 60 cases in each group.The control group was treated with conventional drugs such as oral levodopa benserazide and carbidopa,and the observation group was treated with nerve growth factor on the basis of the control group.After three weeks of treatment,the balance instrument,Berg balance scale and'standing-walking'timing test were used to evaluate the improvement of motor function.Results Before treatment,there was no significant difference in the average center of gravity movement range,the average Berg balance scale score,and the average'standing-walking'time between the two groups(P>0.05).After treatment,they were improved compared with those before treatment,and the improvement of the observation group was better than that of the control group(P<0.05).Conclusion Nerve growth factor adjuvant therapy for Parkinson's disease can significantly improve the motor function of patients,which is worthy of clinical reference.

关 键 词：神经生长因子 帕金森病 运动功能 

分 类 号：R742.5[医药卫生—神经病学与精神病学]