玉米须化学成分研究(Ⅱ)  

Chemical constituents from styles and stigmas of Zea mays(Ⅱ)

作　　者：武二岩 赵明[1,2,3] 时志春 李军 孙立秋[1,2,3] 王丹 赵英楠 WU Eryan;ZHAO Ming;SHI Zhichun;LI Jun;SUN Liqiu;WANG Dan;ZHAO Yingnan(College of Chemistry and Chemical Engineering,Qiqihar University,Qiqihar 161006,China;Heilongjiang Industrial Hemp Processing Technology Innovation Center,Qiqihar 161006,China;Technology Innovation Center of Industrial Hemp,State Administration for Market Regulation,Qiqihar 161006,China)

机构地区：[1]齐齐哈尔大学化学与化学工程学院,黑龙江齐齐哈尔161006 [2]黑龙江省工业大麻加工技术创新中心,黑龙江齐齐哈尔161006 [3]国家市场监督管理总局技术创新中心(工业大麻),黑龙江齐齐哈尔161006

出　　处：《中草药》2024年第22期7583-7590,共8页Chinese Traditional and Herbal Drugs

基　　金：中央支持地方高校改革发展资金人才培养项目(HeiCaiJiao [2021]-137)。

摘　　要：目的 研究玉米Zeamays须醋酸乙酯部位的化学成分。方法 采用硅胶柱色谱,半制备高效液相色谱等技术进行分离纯化,综合应用MS、NMR等现代波谱技术并结合现有文献资料,对得到的单体化合物进行结构鉴定。结果 从玉米须醋酸乙酯部位中分离得到20个化合物,分别鉴定为(2'R)-4-O-(2'-吡咯烷酮)丁酸甲酯(1)、1,3-二羟基-2,4己烯酸丙酯(2)、ryecyanatine A(3)、邻羟基肉桂酸(4)、4-羟基-2丁酮(5)、6,7-二甲氧基-2-苯并噁唑啉酮(6)、吲哚-3-甲醛(7)、阿魏酸(8)、丁二酸单乙酯(9)、玉米烯F(10)、香草酸(11)、对羟基肉桂酸(12)、zeaol B(13)、山梨酸甘油酯(14)、(2R)-2,3-二羟基丙基己酸酯(15)、(2S)-2,3-二羟基丙基己酸酯(16)、对羟基苯甲酸(17)、N-顺式对羟基肉桂酰酸对羟基苯乙胺(18)、N-反式对羟基肉桂酰酸对羟基苯乙胺(19)、壬二酸(20)。结论 化合物1和2为新化合物,分别命名为玉米酰胺A和玉米酯A。化合物14首次作为天然产物分离得到,化合物3、5~7、9、15~16为首次从该植物中分离得到。Objective To study the chemical constituents of the ethyl acetate fraction from styles and stigmas of Zea mays.Methods The compounds were isolated using silica gel column chromatography and subsequently subjected to semi-preparative high-performance liquid chromatography(HPLC)for further purification.Structural elucidation of the isolated compounds was achieved by mass spectrometry(MS)and nuclear magnetic resonance(NMR)spectrometry,corroborated with data from relevant literature.Results A total of twenty compounds were successfully isolated from the ethyl acetate fraction of the styles and stigmas of Zea mays,and their structures were identified as follows:(2'R)-4-O-(2'-pyrrolidinone)methyl butyrate(1),1,3-dihydroxyl-2,4 propylene hexenyl(2),ryecyanatine A(3),o-hydroxy-cinnamic acid(4),4-hydroxy-2-butanone(5),6,7-dimethoxybenzoxazolin-2-one(6),indole-3-carboxaldehyde(7),ferulic acid(8),ethyl succinate(9),zeaene F(10),vanillic acid(11),p-hydroxy-cinnamic acid(12),zeaol B(13),glycerides sorbitate(14),(2R)-2,3-dihydroxypropyl hexanoate(15),(2S)-2,3-dihydroxypropyl hexanoate(16),p-hydroxybenzaldehyde(17),N-(cis-p-coumaroyl)tyramine(18),N-(trans-p-coumaroyl)tyramine(19),azelaic acid(20).Conclusion Compounds 1 and 2 were identified as new compounds and were named zeamide A and zeaolide A,respectively.Compound 14 was first isolated as a natural product.Compounds 3,5-7,9,15 and 16 were isolated from this plant for the first time.

关 键 词：玉米须 玉米酰胺A 玉米酯A 山梨酸甘油酯 1 3-二羟基-2 4己烯酸丙酯 (2'R)-4-O-(2'-吡咯烷酮)丁酸甲酯 

分 类 号：R284.1[医药卫生—中药学]