Apelin-13在阿尔茨海默病中的神经保护作用机制研究进展  

Research advances of the neuroprotective mechanism of apelin-13 in Alzheimer disease

作　　者：刘霖 张文欢 宋雅茹 姜云璐 Liu Lin;Zhang Wenhuan;Song Yaru;Jiang Yunlu(Department of Neurobiology,Jining Medical University,Jining 272067,China;College of Basic Medical,Jining Medical University,Jining 272067,China)

机构地区：[1]济宁医学院神经生物学研究所,272067 [2]济宁医学院基础医学院,272067

出　　处：《中华诊断学电子杂志》2024年第4期276-280,共5页Chinese Journal of Diagnostics(Electronic Edition)

基　　金：山东省大学生创新训练计划项目(S202210443021,S202410443001,S202410443040);济宁医学院校级大学生创新训练计划项目(cx2022027z,cx2022129z)。

摘　　要：阿尔茨海默病(AD)是目前无法治愈且发病率较高的神经退行性疾病,严重威胁着老年人的生活质量和寿命。据统计,全球范围内AD的患病率逐年上升,且AD发病机制复杂,至今尚无有效的治疗方法。近年研究表明,生物活性肽对AD具有神经保护作用。Apelin-13是一种广泛分布于中枢神经系统神经元和少突胶质细胞的神经肽,参与记忆学习过程和预防神经损伤。研究表明,apelin-13可以直接或间接阻止β淀粉样蛋白的产生、抑制磷酸化Tau蛋白的积累、抗炎、抗凋亡,以及通过调节自噬等减缓AD发生进程。笔者主要对apelin-13在AD中保护作用机制的最新研究进展进行综述,为AD的预防和治疗提供新的思路。Alzheimer disease(AD)is a currently incurable neurodegenerative disease with a high incidence rate,which seriously threatens the life quality and lifespan of the eldly.According to statistics,the worldwide incidence of AD worldwide is increasing year by year,and the pathogenesis of AD is complex,with no effective treatment method available to date.Recent studies have shown that bioactive peptides have neuroprotective effects on AD.Apelin-13 is an endogenous neuropeptide,which is widely distributed in neurons and oligodendrocytes of the central nervous system,participating in the processes of memory and learning as well as the prevention of neuronal damage.Studies have shown that apelin-13 can directly or indirectly prevent the production of amyloid-β,inhibit the accumulation of phosphorylated Tau protein,exhibit anti-inflammatory and anti-apoptotic effects,as well s modulate autophagy proless,to slow down the progression of AD.The review mainly focuses on the latest research progress on the protective mechanism of apelin-13 in AD,providing new ideas for the prevention and treatment of AD.

关 键 词：阿尔茨海默病 APELIN-13 炎症 自噬 凋亡 

分 类 号：R749.16[医药卫生—神经病学与精神病学]