GALNT3作为潜在肿瘤分子标志物及药物靶点的研究进展  

Research progress of GALNT3 as a potential tumor molecular marker and drug target

作　　者：高翌轩 张亦弛[1] 戴鹭俨 马皎 GAO Yixuan;ZHANG Yichi;DAI Luyan;MA Jiao(Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China;Department of Biochemistry and Molecular Biology,Shanghai Jiao Tong University College of Basic Medical Science,Shanghai 200025,China)

机构地区：[1]上海交通大学医学院,上海200025 [2]上海交通大学基础医学院生物化学与分子细胞生物学系,上海200025

出　　处：《上海交通大学学报（医学版）》2024年第11期1460-1465,共6页Journal of Shanghai Jiao tong University:Medical Science

基　　金：上海交通大学医学院大学生创新性训练计划(1824081)。

摘　　要：黏蛋白型O-糖基化是蛋白质中最常见的翻译后修饰之一,可以改变蛋白质的空间构象与生物学功能,在细胞信号转导、细胞黏附、免疫应答等生物学过程中发挥着关键作用。而多肽N-乙酰半乳糖胺转移酶3(polypeptide N-acetylgalactosaminyltransferase3,GALNT3)作为黏蛋白型O-糖基化的起始酶,在维持人类细胞和组织的稳态中具有重要意义,而其功能失调已被发现在钙磷代谢紊乱、动脉粥样硬化等多种疾病中发挥作用。此外,GALNT3被发现在结直肠癌、肺癌、卵巢癌等多种肿瘤组织中异常表达,且与患者的临床病理特征和较差预后相关,可以作为肿瘤早期诊断和预后评估的潜在标志物。进一步研究表明,GALNT3既可通过调控糖基化水平,降低肿瘤细胞之间的黏附水平,也可通过激活多条代谢相关通路,促进肿瘤细胞的侵袭转移。该文就GALNT3在恶性肿瘤发生发展中的作用进行综述,并分析了靶向GALNT3开发抗肿瘤药物的前景与挑战。Mucin-type O-glycosylation is one of the most common post-translational modifications in proteins,capable of altering protein conformation and biological functions.It plays a crucial role in biological processes such as cell signaling,cell adhesion,and immune responses.Polypeptide N-acetylgalactosaminyltransferase 3(GALNT3),as the initiating enzyme of mucin-type Oglycosylation,is of paramount importance in maintaining the homeostasis of human cells and tissues.Dysfunction of GALNT3 has been found to play a role in various diseases,such as calcium-phosphorus metabolism disorders and atherosclerosis.Additionally,GALNT3 is abnormally expressed in several types of tumors,including colorectal cancer,lung cancer,and ovarian cancer.Its expression is associated with the clinical pathological features of patients and poor prognosis,making it a potential biomarker for early tumor diagnosis and prognosis evaluation.Further research shows that GALNT3 can both regulate glycosylation levels to reduce adhesion between tumor cells and activate multiple metabolism-related pathways,promoting tumor cell invasion and metastasis.This review summarizes the role of GALNT3 in the development of malignant tumors and discusses the prospects and challenges of developing anti-tumor drugs targeting GALNT3.

关 键 词：多肽N-乙酰半乳糖胺转移酶3 黏蛋白O-糖基化 肿瘤标志物 血液肿瘤 

分 类 号：R730.23[医药卫生—肿瘤]