机构地区:[1]上海市中医医院肿瘤临床医学中心,上海200071 [2]上海市中医医院肿瘤研究所,上海200071 [3]上海市静安区北站医院血液肿瘤科,上海200070 [4]云南省怒江州中医医院肿瘤科,云南泸水673100
出 处:《上海中医药杂志》2024年第12期8-15,共8页Shanghai Journal of Traditional Chinese Medicine
基 金:国家自然科学基金项目(82104943,82174245);上海市卫健委领军人才项目(2022LJ014);上海市炎癌转化病证生物学前沿研究基地项目(2021科技03-12)。
摘 要:目的探讨国内近20年肺癌转移的研究进展及现状,为未来肺癌转移的基础与临床研究提供思路。方法通过中国知网、万方数据知识服务平台、维普中文科技期刊数据库进行文献检索,文献发表时间限定为2003年1月1日至2023年6月30日,语言为中文。应用CiteSpace和VOSviewer软件,对机构、作者、期刊、关键词等进行可视化分析,并绘制相关可视化图谱,分析肺癌转移的研究现状、研究热点及趋势。结果在前述数据库中共检索到符合要求的中文文献6647篇,其中发文量高峰时间在2016年和2020年;发文量最多的机构为上海中医药大学附属龙华医院;总体发文量最多作者为周清华教授,近3年发文量最多作者为田建辉教授;发文量最多的期刊为《中国肺癌杂志》;肺癌转移领域核心热点词为肺癌、非小细胞肺癌、脑转移、骨转移,近3年突现强度排名前3的关键词为靶向治疗、肺腺癌、免疫治疗;近期出现的热点关键词为免疫治疗与影像组学。结论近20年国内肺癌转移研究中,中医、西医出现齐头并进趋势,尤其是中医药领域的机构和专家较为突出,研究方向主要聚焦肺癌的脑转移、骨转移,未来的研究热点或为免疫治疗与影像组学,但肺癌转移机制方面的研究仍需完善与加强。Objective To discuss the research progress and current status of lung cancer metastasis in China in recent 20 years,providing insights for future basic and clinical research on lung cancer metastasis.Methods Literature was retrieved from CNKI,Wanfang,and VIP Databases.The publication period was from January 1,2003 to June 30,2023,and the language was limited to Chinese.CiteSpace and VOSviewer software were used to perform visual analysis on institutions,authors,journals,and keywords,and to draw relevant visual maps to analyze the current status,hotspots,and trends in lung cancer metastasis research.Results A total of 6,647 Chinese articles conforming to the criteria were retrieved from the aforementioned databases.The peak publication years were 2016 and 2020.The institution with the highest number of publications was Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine.The author with the highest overall number of publications was Professor Zhou Qinghua,while the author with the most publications in the past three years was Professor Tian Jianhui.The journal with the highest number of publications was the Chinese Journal of Lung Cancer.Core hotspot keywords in the field of lung cancer metastasis included lung cancer,non-small cell lung cancer,brain metastasis,and bone metastasis.In the past three years,the top three keywords with the highest burst strengths were targeted therapy,lung adenocarcinoma,and immunotherapy.Recently emerging hotspot keywords included immunotherapy and radiomics.Conclusions In the past 20 years,there has been a trend of parallel development in the research of lung cancer metastasis in both traditional Chinese medicine and Western medicine in China.Institutions and experts in the field of traditional Chinese medicine have been particularly prominent.The main research directions have focused on brain and bone metastasis of lung cancer.Future research hotspots may include immunotherapy and radiomics,but research on lung cancer metastasis mechanisms needs furthe
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