注射用丹参多酚酸联合常规西药治疗短暂性脑缺血发作患者的效果  

Effects of Salvianolic acids for injection combined with conventional Western medicine in treatment of patients with transient ischemic attack

作　　者：朱莎莎[1] 王燕[2] ZHU Shasha;WANG Yan(Anyang People’s Hospital No.6,WardⅢof Department of Neurology,Anyang 455000 Henan,China;Anyang People’s Hospital No.6,WardⅠof Department of Neurology,Anyang 455000 Henan,China)

机构地区：[1]安阳市第六人民医院,神经内科三病区,河南安阳455000 [2]安阳市第六人民医院神经内科一病区,河南安阳455000

出　　处：《中国民康医学》2024年第23期66-68,73,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:观察注射用丹参多酚酸联合常规西药治疗短暂性脑缺血发作(TIA)患者的效果。方法:回顾性分析2022年1—12月该院收治的112例TIA患者的临床资料,按照治疗方法不同将其分为研究组和对照组各56例。两组均进行基础治疗,在此基础上,对照组采用常规西药(阿司匹林+氯吡格雷)治疗,研究组在对照组基础上联合注射用丹参多酚酸治疗,两组均连续治疗2周。比较两组临床疗效,治疗前后大脑动脉峰值流速、血小板相关因子[血栓素B2(TXB2)、环磷酸腺苷(cAMP)]水平,治疗后6个月脑梗死发生率,以及不良反应发生率。结果:研究组治疗总有效率为94.64%(53/56),高于对照组的82.14%(46/56),差异有统计学意义(P<0.05);治疗后,两组大脑前动脉、大脑中动脉、大脑后动脉等大脑动脉峰值流速均高于治疗前,且研究组高于对照组,差异有统计学意义(P<0.05);治疗后,两组TXB2水平均低于治疗前,且研究组低于对照组,两组cAMP水平均高于治疗前,且研究组高于对照组,差异有统计学意义(P<0.05);研究组脑梗死发生率低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:注射用丹参多酚酸联合常规西药治疗TIA患者可提高治疗总有效率和大脑动脉峰值流速,改善血小板相关因子水平,降低脑梗死发生率,效果优于单纯常规西药物治疗。Objective:To observe effects of Salvianolic acids for injection combined with conventional Western medicine in treatment of patients with transient ischemic attack(TIA).Methods:The clinical data of 112 patients with TIA admitted to this hospital from January to December 2022 were retrospectively analyzed.According to different treatment methods,they were divided into study group and control group,56 cases in each group.Both groups received basic treatment.On this basis,the control group was treated with conventional Western medicine(Aspirin+Clopidogrel),while the study group was treated with Salvianolic acid for injection on the basis of that of the control group.Both groups were treated for 2 weeks.The clinical efficacy,the cerebral artery peak velocity,the platelet-related factors[thromboxane B2(TXB2),cyclic adenosine monophosphate(cAMP)]levels before and after the treatment,the incidence of cerebral infarction at 6 months after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the study group was 94.64%(53/56),which was higher than 82.14%(46/56)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the peak flow velocity of anterior cerebral artery,middle cerebral artery and posterior cerebral artery in the two groups were higher than those before the treatment,those in the study group were higher than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of TXB2 in the two groups were lower than those before the treatment,and that in the study group was lower than that in the control group;the levels of cAMP in the two groups were higher than those before the treatment,and that in the study group was higher than that in the control group;and the differences were statistically significant(P<0.05).The incidence of cerebral infarction in the study group was lower than that in the control group,the difference was statistically signifi

关 键 词：短暂性脑缺血发作 注射用丹参多酚酸 阿司匹林 氯吡格雷 大脑动脉峰值流速 血小板相关因子 脑梗死 

分 类 号：R743.31[医药卫生—神经病学与精神病学]