宫颈癌组织Survivin、HPV16E7水平与患者临床病理特征、预后及化疗敏感性的关系研究  

Relationship Between Survivin and HPV16E7 Levels in Cervical Cancer Tissues and Patient Clinicopathological Characteristics,Prognosis and Chemotherapy Sensitivity

作　　者：崔光娥 文帅 刘英杰 宋庆 井雪源 孙淑军 Cui Guange;Wen Shuai;Liu Yingjie(Oncology and Hematology Department,Pingdingshan Medical District,The 989th Hospital,Joint Logistic Support Force,Pingdingshan,Henan,467000,China)

机构地区：[1]联勤保障部队第九八九医院平顶山医疗区肿瘤血液科,河南平顶山467000

出　　处：《黑龙江医学》2024年第24期2960-2963,共4页Heilongjiang Medical Journal

摘　　要：目的:探究宫颈癌(CC)组织生存蛋白(Survivin)、人乳头瘤病毒16型E7基因片段(HPV16E7)水平与患者临床病理特征、预后及化疗敏感性的关系。方法:选取2020年7月—2022年4月联勤保障部队第九八九医院平顶山医疗区收治的118例CC化疗患者作为研究对象,检测组织Survivin、HPV16E7表达情况,并分析其与临床病理特征、总生存期(OS)、化疗敏感性的关系。结果:组织Survivin阳性表达与FIGO分期、组织分化、淋巴结转移具有密切的相关性,组织HPV16E7阳性表达与FIGO分期相关,差异均有统计学意义(χ^(2)=23.741、18.819、15.311、7.715,P<0.05)。不同分期下,OS<6个月患者组织HPV16E7阳性表达率均高于OS≥6个月患者,差异均有统计学意义(χ^(2)=6.667、6.089,P<0.05)。化疗敏感患者组织Survivin、HPV16E7阳性表达率均低于化疗抵抗患者,差异均有统计学意义(χ^(2)=23.248、7.859,P<0.05)。Survivin与HPV16E7mRNA表达水平呈正相关(r=0.326,P<0.05)。结论:CC组织Survivin、HPV16E7水平与患者临床病理特征、预后及化疗敏感性具有密切的相关性。Objective:To explore the relationship between tissue survival protein(Survivin),E7 segment of human papllomavirus 16E7(HPV16E7)and clinicopathological characteristics,prognosis and chemotherapy sensitivity of patients.Methods:118 CC patients treated with chemotherapy from July 2020 to April 2022 were selected for the expression of tissue Survivin and HPV16E7.The relationship with clinicopathological characteristics,overall survival(OS),and chemotherapy sensitivity were analyzed.Results:Survivin positive expression in tissues was closely correlated with FIGO stage,tissue differentiation,and lymph node metastasis,while HPV16E7 positive expression in tissues was significantly correlated with FIGO stage(χ^(2)=23.741,18.819,15.311,7.715;P<0.05).The HPV16E7 positive expression rate of 0S<6 months was higher than that of 0S≥6 months at different stages,and the difference was statistically significant(χ^(2)=6.667,6.089;P<0.05).The positive expression rates of Survivin and HPV16E7 in chemotherapy sensitive tissues were lower than those in chemotherapy resistance,with statistically significant difference(χ^(2)=23.248,7.859;P<0.05).Survivin was positively correlated with HPV16E7 mRNA expression(r=0.326,P<0.05).Conclusion:The levels of Survivin and HPV16E7 are closely related with the clinicopathological characteristics of patients.

关 键 词：宫颈癌 生存蛋白 人乳头瘤病毒16型E7基因片段 临床病理特征 预后 化疗敏感性 

分 类 号：R737.33[医药卫生—肿瘤]