难治性抑郁症采用舒肝解郁胶囊联合艾司西酞普兰治疗的临床效果分析  

Clinical Efficacy Analysis of Shugan Jieyu Capsules Combined with Escitalopram in the Treatment of Refractory Depression

作　　者：张霞波 方晓婷 张俊 薛莲[1] ZHANG Xiabo;FANG Xiaoting;ZHANG Jun;XUE Lian(Changshu Third People's Hospital,Changshu 215500,Jiangsu,China)

机构地区：[1]常熟市第三人民医院,江苏常熟215500

出　　处：《系统医学》2024年第22期68-70,74,共4页Systems Medicine

摘　　要：目的探讨舒肝解郁胶囊联合艾司西酞普兰治疗难治性抑郁症的疗效。方法非随机选取2022年8月—2023年8月常熟市第三人民医院精神科收治的98例难治性抑郁症患者为研究对象,按治疗方法分为两组,每组49例。对照组使用草酸艾司西酞普兰片治疗,观察组使用舒肝解郁胶囊联合草酸艾司西酞普兰片治疗。对比两组脑源性神经营养因子(brain-derived neurotrophic factor,BDNF)、P物质(substance P,SP)、疗效及不良反应。结果治疗后,观察组BDNF水平高于对照组,SP水平低于对照组,差异有统计学意义(P均<0.05)。观察组总有效率为95.92%(47/49),高于对照组的81.63%(40/49),差异有统计学意义(χ^(2)=5.018,P<0.05)。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论难治性抑郁症的临床治疗中采用舒肝解郁胶囊联合艾司西酞普兰治疗效果理想,且具有较高的安全性。Objective To explore the clinical efficacy of Shugan Jieyu Capsules combined with escitalopram in the treatment of refractory depression.Methods Ninety-eight patients with refractory depression admitted to the Department of Psychiatry of Changshu Third People's Hospital from August 2022 to August 2023 were non-randomly selected as the study subjects,and were divided into two groups according to treatment methods,with forty-nine cases in each group.The control group was treated with escitalopram oxalate tablets,and the observation group was treated with Shugan Jieyu Capsules combined with escitalopram oxalate tablets.The two groups were compared in terms of brain-derived neurotrophic factor(BDNF),substance P(SP),efficacy and adverse reactions.Results After treatment,the BDNF level of the observation group was higher than that of the control group,and the SP level was lower than that of the control group,and the differences were statistically significant(both P<0.05).The total effective rate of the observation group was 95.92%(47/49),which was higher than 81.63%(40/49)of the control group,and the difference was statistically significant(χ^(2)=5.018,P<0.05).There was no statistically significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion The clinical treatment of refractory depression is more effective and has a higher safety profile with the use of liver relief capsules combined with escitalopram.

关 键 词：难治性抑郁症 舒肝解郁胶囊 艾司西酞普兰 疗效 

分 类 号：R749[医药卫生—神经病学与精神病学]