肿瘤电场治疗在胶质母细胞瘤中的研究进展  

Advances in the study of the role of tumor treating fields therapy in the treatment of glioblastoma

作　　者：杜爱超 程厚翔 代军强[1,2,3] 潘亚文[1,2,3] Du Aichao;Cheng Houxiang;Dai Junqiang;Pan Yawen(Second Clinical Medical School of Lanzhou University,Lanzhou 730030,China;Institute of Neurosurgery,Second Hospital of Lanzhou University,Lanzhou 730030,China;Department of Neurosurgery,Second Hospital of Lanzhou University,Lanzhou 730030,China)

机构地区：[1]兰州大学第二临床医学院,兰州730030 [2]兰州大学第二医院神经外科研究所,兰州730030 [3]兰州大学第二医院神经外科,兰州730030

出　　处：《国际肿瘤学杂志》2024年第10期639-644,共6页Journal of International Oncology

基　　金：甘肃省自然科学基金(23JRRA1645)。

摘　　要：胶质母细胞瘤(GBM)是中枢神经系统最具威胁的疾病之一,尽管治疗方法不断更新,但患者预后并未得到改善。然而,肿瘤电场治疗(TTField)的引入改变了新诊断和复发性GBM的治疗方式。TTField是一种利用中频低强度交变电场治疗肿瘤的新型无创疗法,对于GBM等中枢神经系统疾病的治疗有重要意义。与传统治疗方式相比,TTField具有较小的不良反应和较好的局部疗效。此外,化疗药物和放疗与TTField的联合应用已被证明具有显著优势,可能成为未来临床治疗的策略之一。然而,尽管TTField在GBM治疗中具有较大潜力,但仍存在一些局限性,包括治疗设备的依赖性、使用过程中的不适感以及部分患者对该治疗的耐受性等问题。因此,需要进一步优化TTField的使用方式,以最大程度地发挥其在GBM患者中的治疗潜力,为患者提供更有效的治疗方案。Glioblastoma(GBM)is one of the most threatening diseases of the central nervous system,and the prognosis has not improved despite the constant updating of therapeutic approaches.However,the introduction of tumor treating fields(TTFields)has changed the treatment of newly diagnosed and recurrent GBM.TTFields is a novel non-invasive therapy for the treatment of tumors using mid-frequency and lowintensity alternating electric fields,which is important for the treatment of central nervous system diseases such as GBM.TTFields has fewer side effects and greater local efficacy than traditional treatment modalities.In addition,the combination of chemotherapeutic drugs and radiotherapy with TTFields has shown significant advantages and may become one of the future clinical treatment strategies.Despite the potential of TTFields in the treatment of GBM,a number of limitations remain,including issues of device dependency,discomfort during use and tolerability in some patients.Therefore,the use of TTFields needs to be further optimized to maximize their therapeutic potential in patients with GBM and to provide more effective treatment options for patients.

关 键 词：胶质母细胞瘤 胶质瘤 肿瘤电场治疗 机制 

分 类 号：R739.4[医药卫生—肿瘤]