肝癌肿瘤微环境与消融治疗的研究现状与展望  

Research status and prospect of tumor microenvironment and ablation therapy for liver cancer

作　　者：何佩霈 杨朝凤 李杨[1,2] He Peipei;Yang Chaofeng;Li Yang(Department of Radiology,Affiliated Hospital of North Sichuan Medical College,Nanchong 637000,China;Department of Radiology,People's Hospital of Yuechi County of Sichuan Province,Yuechi 638300,China)

机构地区：[1]川北医学院附属医院放射科,南充637000 [2]四川省岳池县人民医院放射科,岳池638300

出　　处：《国际肿瘤学杂志》2024年第10期655-659,共5页Journal of International Oncology

基　　金：南充市校科技战略合作专项(22SXQT0294);广安市科技创新指导性计划(2022zdxjh18);川北医学院校级科研发展计划(CBY23-QNA51)。

摘　　要：肝癌是常见的恶性肿瘤之一,大多数患者就诊时已处于中晚期。消融治疗是早期肝癌或无法手术切除肝癌患者主要的治疗方法。肿瘤微环境的变化可能会对肝癌消融术后患者的疗效及预后产生影响。近年来,越来越多的研究探索肝癌消融治疗与肿瘤微环境之间潜在的协同作用,以改善消融治疗疗效并提高生存率。探讨肝癌肿瘤微环境的关键组成部分及肿瘤微环境在肝癌消融治疗中发挥的免疫调节作用,可为肝癌治疗提供新策略。Liver cancer is one of the common malignant tumors,and most patients are in the middle and advanced stages when they seek medical attention.Ablation therapy is the main treatment for patients with early or unresectable liver cancer.Changes in the tumor microenvironment may affect the efficacy and prognosis of patients after ablation of liver cancer.In recent years,more and more studies have explored the potential synergistic effect between ablation therapy for liver cancer and the tumor microenvironment to improve the efficacy of ablation therapy and improve survival rate.Exploring the key components of the tumor microenvironment and the immunomodulatory role of the tumor microenvironment in the ablation treatment of liver cancer can provide a new strategy for the treatment of liver cancer.

关 键 词：癌 肝细胞 肿瘤微环境 介入治疗 

分 类 号：R735.7[医药卫生—肿瘤]