内镜下金属钛夹与注射肾上腺素治疗ANVUGIB患者的效果比较  

Comparison of the effects of endoscopic metal titanium clips and epinephrine injection in the treatment of ANVUGIB patients

作　　者：王冬青 杜敏 WANG Dongqing;DU Min(Digestive Endoscopy Center,Fuping County Hospital,Weinan 711700,China;Gastroenterology Department,Fuping County Hospital,Weinan 711700,China)

机构地区：[1]富平县医院消化内镜中心,陕西渭南711700 [2]富平县医院消化内科,陕西渭南711700

出　　处：《临床医学研究与实践》2024年第34期63-66,共4页Clinical Research and Practice

摘　　要：目的比较内镜下金属钛夹与注射肾上腺素治疗急性非静脉曲张性上消化道出血(ANVUGIB)患者的效果。方法选取2020年1月至2022年12月我院收治的150例ANVUGIB患者作为研究对象,按照入院先后顺序将其分为对照组和研究组,各75例。对照组采取内镜下注射肾上腺素治疗,研究组采取内镜下金属钛夹治疗。比较两组的治疗效果、症状恢复时间、血清指标及生长因子指标。结果研究组的治疗总有效率显著高于对照组,止血时间、肠蠕动恢复时间、大便潜血试验转阴时间短于对照组(P<0.05)。治疗后,研究组的皮质醇(Cor)、一氧化氮(NO)、抗利尿激素(ADH)、丙二醛(MDA)、血管紧张素转化酶(ACE)水平低于对照组(P<0.05)。治疗后,研究组的表皮生长因子(EGF)、表皮生长因子受体(EGFR)、转化生长因子-α(TGF-α)水平高于对照组(P<0.05)。结论相较于注射肾上腺素,内镜下金属钛夹治疗ANVUGIB的效果更佳,其可缩短患者症状恢复时间,调节生长因子指标,具有更高的应用价值。Objective To compare the effects of endoscopic metal titanium clips and epinephrine injection in the treatment of acute nonvariceal upper gastrointestinal bleeding(ANVUGIB)patients.Methods A total of 150 patients with ANVUGIB admitted in our hospital from January 2020 to December 2022 were selected as the research objects.According to the order of admission,the patients were divided into control group and study group,with 75 cases in each group.The control group was treated with endoscopic injection of epinephrine,and the study group was treated with endoscopic metal titanium clip.The therapeutic effect,symptom recovery time,serum indexes and growth factors indexes were compared between the two groups.Results The total effective rate of treatment in the study group was significantly higher than that in the control group,and the hemostasis time,intestinal peristalsis recovery time and fecal occult blood test negative time were shorter than those in the control group(P<0.05).After treatment,the levels of cortisol(Cor),nitric oxide(NO),antidiuretic hormone(ADH),malondialdehyde(MDA)and angiotensin converting enzyme(ACE)in the study group were lower than those in the control group(P<0.05).After treatment,the levels of epidermal growth factor(EGF),epidermal growth factor receptor(EGFR)and transforming growth factor-α(TGF-α)in the study group were higher than those in the control group(P<0.05).Conclusion Compared with the injection of epinephrine,endoscopic metal titanium clip is more effective in the treatment of ANVUGIB,which can shorten the recovery time of patients'symptoms and regulate the growth factors indexes,and has higher application value.

关 键 词：急性非静脉曲张性上消化道出血 内镜 金属钛夹 肾上腺素 

分 类 号：R573.2[医药卫生—消化系统]