Association of fluoride exposure with disease burden and neurodevelopment outcomes in children in South Korea  

作　　者：Won Seok Lee Ju Hee Kim Boeun Han Gi Chun Lee Hye Ri Jung Ye Jin Shin Eun Kyo Ha Eun Lee Soonchul Lee Man Yong Han 

机构地区：[1]Department of Pediatrics,CHA Ilsan Medical Center,CHA University School of Medicine,Goyang,Republic of Korea [2]Department of Pediatrics,Kyung Hee University Hospital,Kyung Hee University College of Medicine,Seoul,Republic of Korea [3]Department of Pediatrics,CHA Bundang Medical Center,CHA University School of Medicine,59 Yatap-Ro,Bundang-Gu,Seongnam-si,Gyeonggi-do,13496,Republic of Korea [4]Multi-Omics Research Center,CHA Future Medicine Research Institute,Seongnam,Republic of Korea [5]Department of Computer Science and Engineering,Konkuk University,Seoul,Republic of Korea [6]School of Medicine,CHA University,Pocheon,Republic of Korea [7]Department of Pediatrics,Hallym University Kangnam Sacred Heart Hospital,Hallym University College of Medicine,Seoul,Republic of Korea [8]Department of Pediatrics,Chonnam National University Hospital,Chonnam National University Medical School,Gwangju,Republic of Korea [9]Department of Orthopaedic Surgery,CHA Bundang Medical Center,CHA University School of Medicine,59 Yatap-Ro,Bundang-Gu,Seongnam-si,Gyeonggi-do,13496,Republic of Korea

出　　处：《World Journal of Pediatrics》2024年第10期1029-1042,共14页世界儿科杂志（英文版）

基　　金：supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute(KHIDI);funded by the Ministry of Health&Welfare,Republic of Korea(grant number:HR22C1605);by the National Research Foundation of Korea(NRF)grant funded by the Korea government(MSIT)(NRF-2022R1A2C2005916).

摘　　要：Background Community water fluoridation is an effective public health strategy for preventing dental caries,yet.Concerns exist about potential health problems.This study explores associations between tap water fluoride levels and pediatric disease burden,as well as neurodevelopmental outcomes at 6 years of age.Methods This nationwide population-based cohort study included children born in Korean cities with and without tap water fluoridation projects,between 2006 and 2012,aiming for a fluoride concentration of 0.8±0.2 mg/L in treated tap water.Data from the National Health Insurance Service were used,spanning from birth to 2018.The relationship between exposure to fluoridated tap water and incidence of 16 childhood diseases that were previously identified as potentially linked to fluoride exposure were examined.Additionally,we evaluated the neurodevelopmental outcomes across various domains,including gross motor,fine motor,cognition,language,social skills,and self-help functions.These assessments were performed using data from a comprehensive national health screening program for children aged six years.Results A fluoride-unexposed group included 22,881 children,whereas a fluoride-exposed group comprised 29,991 children(52%males).Children in the fluoride-exposed group had a decreased risk of dental caries and bone fractures[hazard ratio(95%confidence interval,CI),0.76(0.63–0.93)and 0.89(0.82–0.93),respectively]and increased risk of hepatic failures[1.85,(1.14–2.98)]compared to those in the unexposed group.Additionally,the risk ratio of abnormal neurodevelopmental screening outcomes increased by 9%,but this was statistically uncertain(95%CI,0.95–1.26).Conclusions Fluoridated tap water was associated with an increased risk of hepatic failure but a decreased risk of bone fractures in children.The association between fluoridated tap water and neurodevelopmental screening outcomes at 6 years remains unclear,highlighting the need for further studies to clarify this association.

关 键 词：CHILDREN FLUORIDE Hepatic failure NEURODEVELOPMENT 

分 类 号：R338[医药卫生—人体生理学]