全身免疫炎症指数在溃疡性结肠炎病情评估中的应用价值  

The application value of systemic immune inflammation index in the assessment of ulcerative colitis

作　　者：于豆豆 李兴武 YU Doudou;LI Xingwu(Department of Clinical Laboratory,the First Affiliated Hospital of Bengbu Medical University,Bengbu,Anhui 233000,China)

机构地区：[1]蚌埠医科大学第一附属医院检验科,安徽蚌埠233000

出　　处：《检验医学与临床》2024年第S02期100-103,共4页Laboratory Medicine and Clinic

摘　　要：目的探讨外周血全身免疫炎症指数(SⅡ)与溃疡性结肠炎(UC)活动性及病情严重程度的相关性,评估其在UC疾病活动中的预测价值。方法回顾性收集2020年11月至2023年11月在该院消化内科或胃肠外科初次就诊的100例UC患者作为实验组,并选取同期健康志愿者60例作为对照组。依据改良Mayo活动指数将UC实验组分为缓解组和活动组(轻度、中度、重度);依据蒙特利分级将UC实验组分为E1、E2、E3组。比较外周血SⅡ水平与UC和活动程度、病变范围的关系,评估其对UC病情的预测价值。结果与对照组相比,UC组外周血白细胞计数、血小板计数、SⅡ、C反应蛋白、红细胞沉率水平较健康人升高,差异有统计学意义(P<0.05)。UC和对照组间年龄、性别差异无统计学意义(P>0.05)。活动期患者SⅡ高于缓解期患者,差异有统计学意义(P<0.05)。随着活动程度和病变范围的增加,SⅡ水平呈递增趋势,呈弱正相关,差异有统计学意义(P<0.05)。用受试者工作特征(ROC)曲线评估SⅡ预测UC疾病活动的价值时,结果显示ROC曲线下面积为0.822,95%CI为0.730~0.913(P<0.01),灵敏度为78.10%,特异度为77.80%。结论UC患者外周血SⅡ水平与疾病活动程度和病变范围呈正相关,可有效监测疾病活动。Objective To investigate the correlation between systemic immune inflammation index(SⅡ)in the peripheral blood and the severity of ulcerative colitis(UC)activity and to evaluate its predictive value in UC activity.Methods A total of 100 UC patients who first visited the gastroenterology department or gastrointestinal surgery department of the hospital from November 2020 to November 2023 were retrospectively collected as the experimental group,and 60 healthy volunteers of the same period were selected as the control group.According to the modified Mayo activity index,the experimental group was divided into remission group and activity group(mild,moderate and severe).The experimental group was divided into E1,E2 and E3 groups according to Monterey classification.To compare the relationship between SⅡand UC,the degree of activity and the extent of lesion,and evaluate the predictive value of UC disease.Results Compared with the control group,the levels of white blood cell count,platelet count,SⅡ,CRP and ESR in the peripheral blood of the UC group were higher than those in normal controls,and the differences were statistically significant(P<0.05).There were no statistically significant differences in age and gender between UC and normal groups(P>0.05).The SⅡlevel of patients in active stage was higher than that in remission stage,and the difference was statistically significant(P<0.05).With the increase of activity degree and lesion scope,SⅡlevel showed an increasing trend,showing a weak positive correlation,and the difference was statistically significant(P<0.05).ROC curve was used to evaluate the value of SⅡin predicting UC disease activity.The area under ROC curve was 0.822,and 95%CI was 0.730 to 0.913(P<0.01),the sensitivity was 78.10%,the specificity was 77.80%.Conclusion The level of SⅡin the peripheral blood of UC patients is positively correlated with the degree of disease activity and the scope of disease,which can effectively monitor the disease activity.

关 键 词：全身免疫炎症指数 溃疡性结肠炎 疾病活动程度 病变范围 

分 类 号：R574.62[医药卫生—消化系统]