睡眠障碍影响口腔溃疡后黏膜愈合机制的研究进展  

Research progress on sleep disorders affecting mucosa healing mechanism after oral ulcer

作　　者：黄旗 刘珂灏 黄子煜 杨生 李雨舟 HUANG Qi;LIU Kehao;HUANG Ziyu;YANG Sheng;LI Yuzhou(Stomatological Hospital of Chongqing Medical University,Chongqing 401147,China;Chongqing Municipal Key Laboratory of Oral Disease and Biomedical Sciences,Chongqing 401147,China;Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education,Chongqing 401147,China)

机构地区：[1]重庆医科大学口腔医学院,重庆401147 [2]口腔疾病与生物医学重庆市重点实验室,重庆401147 [3]重庆市高校市级口腔生物医学工程重点实验室,重庆401147

出　　处：《重庆医学》2024年第23期3645-3650,共6页Chongqing Medical Journal

基　　金：国家自然科学基金面上项目(82370973);国家自然科学基金青年项目(82001103);国家自然基金面上项目(82171010)。

摘　　要：口腔溃疡是指黏膜上皮完整性发生破坏,其发生、发展受系统性疾病、遗传、免疫及全身亚健康状态等多种因素影响。睡眠与人体健康密切相关,长期的睡眠障碍可导致内分泌紊乱、免疫失调及代谢疾病。流行病学研究发现,睡眠质量与黏膜愈合密切相关,睡眠障碍是黏膜愈合受损的潜在风险因素。动物研究证实,睡眠剥夺加重大鼠口腔溃疡症状,延迟口腔溃疡愈合,但其确切细胞及分子机制尚不明确。该文对睡眠障碍影响口腔溃疡后黏膜愈合的机制进行综述,以期为口腔溃疡后黏膜愈合和软组织再生的基础研究和治疗提供理论依据。Oral ulcers refers to the disruption occurrence of mucosal epithelial integrity,its occurrence and development are affected by a variety of factors such as systemic diseases,genetics,immunity and systemic subhealth state;sleep is closely related to human health,and long-term sleep disturbance can lead to endocrine disorders,immune disorders,and metabolic diseases.Epidemiologic studies find that sleep quality is closely related to mucosal healing,and sleep disorders may be a potential risk factor for impaired mucosal healing.The animal experiments verify that sleep deprivation exacerbates oral ulcer symptoms and delays the oral ulcer healing in rats,but the exact cellular and molecular mechanisms are unclear.This paper reviews the mechanisms of sleep disorders in affecting mucous membrane healing after oral ulcer in order to provide a theoretical basis for basic research and treatment of mucosal healing and soft tissue regeneration.

关 键 词：睡眠障碍 失眠 口腔溃疡 黏膜再生 黏膜愈合 综述 

分 类 号：R781[医药卫生—口腔医学]