康艾注射液联合一线化疗治疗晚期结直肠癌患者的临床疗效  

Clinical efficacy of Kang efficacy of Kang’ai injection combined with first-line chemotherapy in ai the treatment of patients with advanced colorectal cancer

作　　者：张林锋 罗景方 张有华 ZHANG Linfeng;LUO Jingfang;ZHANG Youhua(Department of Medical Oncology,First People's Hospital of Fuzhou,Fuzhou 344000,Jiangxi,China)

机构地区：[1]抚州市第一人民医院肿瘤内科,江西抚州344000

出　　处：《癌症进展》2024年第21期2345-2347,2383,共4页Oncology Progress

摘　　要：目的 探讨康艾注射液联合一线化疗治疗晚期结直肠癌患者的临床疗效。方法 根据治疗方案的不同将60例晚期结直肠癌患者分为对照组(n=28,一线化疗)和联合组(n=32,康艾注射液联合一线化疗)。比较两组患者的临床疗效、肝功能指标[丙氨酸转氨酶(ALT)、总胆红素(TBIL)、碱性磷酸酶(ALP)]、免疫功能指标(CD3^(+)、CD4^(+)、CD8^(+))及不良反应发生情况。结果 两组患者的疾病控制率比较,差异无统计学意义(P﹥0.05)。治疗后,联合组患者ALT、TBIL、ALP、CD8^(+)水平均低于对照组,CD3^(+)、CD4^(+)水平均高于对照组,差异均有统计学意义(P﹤0.05)。联合组患者的不良反应总发生率低于对照组,差异有统计学意义(P﹤0.05)。结论 康艾注射液联合一线化疗治疗晚期结直肠癌患者具有一定的疗效,可减轻肝功能损伤,提高免疫功能,减少不良反应。Objective To investigate the clinical efficacy of Kang’ai injection combined with first-line chemothera-py in the treatment of patients with advanced colorectal cancer.Method According to the different treatment regimens,60 patients with advanced colorectal cancer were divided into control group(n=28,first-line chemotherapy)and combination group(n=32,Kang’ai injection combined with first-line chemotherapy).The clinical efficacy,liver function indexes[alanine aminotransferase(ALT),total bilirubin(TBIL),alkaline phosphatase(ALP)],immune function indexes(CD3^(+),CD4^(+),CD8^(+))and adverse reactions were compared between the two groups.Result There was no significant difference in disease control rate between the two groups(P>0.05).After treatment,the ALT,TBIL,ALP and CD8^(+)levels in combination group were lower than those in control group,and the CD3^(+)and CD4^(+)levels were higher than those in control group,and the differences were statistically significant(P<0.05).The total incidence of adverse reactions in combination group was lower than that in control group,and the difference was statistically significant(P<0.05).Conclusion Kang’ai injection combined with first-line chemotherapy in the treatment of advanced colorectal cancer patients has a certain effect,and can reduce liver function injury,improve immune function,reduce adverse reactions.

关 键 词：晚期结直肠癌 康艾注射液 化疗 临床疗效 肝功能 

分 类 号：R735.3[医药卫生—肿瘤]