内生型宫颈癌患者人乳头瘤病毒分型及与临床特征和预后的关系  

Human papilloma virus typing and its relationship with clinical characteristic and prognosis in patients with endogenous cervical cancer

作　　者：冯若琳 师娟 孙利娟 FENG Ruolin;SHI Juan;SUN Lijuan(Department of Gynecology and Obstetrics,Hebi People's Hospital,Hebi 458030,He'nan,China)

机构地区：[1]鹤壁市人民医院妇产科,河南鹤壁458030

出　　处：《癌症进展》2024年第21期2384-2386,2391,共4页Oncology Progress

摘　　要：目的 探讨内生型宫颈癌(ECCA)患者人乳头瘤病毒(HPV)分型及与临床特征和预后的关系。方法 选取120例ECCA患者作为研究组,另选取90例外生型宫颈癌患者作为对照组,全部患者均存在HPV感染,入院时检测HPV分型。比较两组患者的HPV分型,分析HPV分型与ECCA患者临床特征的关系。随访12个月,采用Cox回归模型分析ECCA患者预后的影响因素。结果 研究组患者31/51型HPV感染发生率明显高于对照组,16/18型HPV感染发生率明显低于对照组,差异均有统计学意义(P﹤0.01)。不同临床分期、淋巴结转移情况ECCA患者HPV分型比较,差异均有统计学意义(P﹤0.05)。多因素分析结果显示,HPV分型为31/51型、有淋巴结转移均为ECCA患者预后的独立危险因素(P﹤0.01)。结论 ECCA患者的HPV分型多为31/51型,31/51型HPV感染、淋巴结转移均是ECCA患者预后的独立危险因素。Objective To investigate the typing of human papilloma virus(HPV)and its relationship with clinical characteristics and prognosis in patients with endogenous cervical cancer(ECCA).Method A total of 120 patients with ECCA were selected as the study group,and 90 patients with exceptional cervical cancer were selected as the control group.All patients had HPV infection,HPV typing was detected at admission.The HPV typing of the two groups was compared,and the relationship between HPV typing and clinical characteristics of ECCA patients was analyzed.After 12 months of follow-up,Cox regression model was used to analyze the prognostic factors of ECCA patients.Result The incidence rate of HPV31/51 infection in the study group was significantly higher than that in the control group,and the incidence rate of HPV16/18 infection was significantly lower than that in the control group,the differences were statistically significant(P<0.01).There were significant differences in HPV typing among ECCA patients with different clinical stages and lymph node metastasis(P<0.05).The results of multivariate analysis showed that HPV type 31/51 and lymph node metastasis were independent risk factors for prognosis in ECCA patients(P<0.01).Conclusion Most of the HPV typing in ECCA patients are 31/51,and HPV31/51 infection and lymph node metastasis are independent risk factors for prognosis of ECCA patients.

关 键 词：内生型宫颈癌 人乳头瘤病毒感染 人乳头瘤病毒分型 临床特征 预后 

分 类 号：R737.33[医药卫生—肿瘤]