多模态MRI检查在脑胶质瘤术前分级及术后疗效评估中的应用价值  

Application value of multimodal MRI examination in preoperative grading and postoperative efficacy evaluation of brain glioma

作　　者：刘天笑 周晶 贺曦 LIU Tianxiao;ZHOU Jing;HE Xi(Department of Imaging,Pingxiang People'sHospital,Pingxiang 337000,Jiangxi,China)

机构地区：[1]萍乡市人民医院影像科,江西萍乡337000

出　　处：《癌症进展》2024年第21期2396-2399,共4页Oncology Progress

基　　金：江西省卫生健康委科技计划项目(202311704)。

摘　　要：目的 探讨多模态MRI检查在脑胶质瘤(BG)术前分级及术后疗效评估中的应用价值。方法 根据病理检查结果将60例BG手术患者分为低级别BG组(n=30)和高级别BG组(n=30),术前两组患者均行多模态MRI检查,比较低级别BG组和高级别BG组患者表观弥散系数(ADC)、脑血流量(CBF)及胆碱(Cho)/肌酸(Cr)。根据术后疗效将60例BG手术患者分为治疗有效组(n=45)和治疗无效组(n=15),比较治疗有效组和治疗无效组患者ADC、CBF及Cho/Cr。采用受试者工作特征(ROC)曲线及曲线下面积(AUC)分析ADC、CBF、Cho/Cr单独及联合检测对高级别BG的诊断价值以及对BG患者术后疗效的预测价值。结果 低级别BG组患者ADC高于高级别BG组,CBF及Cho/Cr均低于高级别BG组,差异均有统计学意义(P﹤0.05)。ADC、CBF及Cho/Cr联合检测诊断高级别BG的AUC为0.883,高于各项指标单独检测。治疗有效组患者的ADC高于治疗无效组,CBF及Cho/Cr均低于治疗无效组,差异均有统计学意义(P﹤0.05)。ADC、CBF及Cho/Cr联合检测预测BG患者术后疗效的AUC为0.878,高于各项指标单独检测。结论 多模态MRI检查可用于BG术前分级及术后疗效评估,在BG临床诊治中具有重要指导意义。Objective To explore the application value of multimodal MRI examination in preoperative grading and postoperative efficacy evaluation of brain glioma(BG).Method According to the results of pathological examination,60 BG patients were divided into low-grade BG group(n=30)and high-grade BG group(n=30).Both groups underwent multimodal MRI examination before surgery.The apparent diffusion coeffecient(ADC),cerebral blood flow(CBF)and choline(Cho)/creatine(Cr)were compared between the low-grade BG group and the high-grade BG group.According to the postoperative efficacy,60 BG patients were divided into effective treatment group(n=45)and ineffective treatment group(n=15).The ADC,CBF and Cho/Cr were compared between the effective treatment group and the ineffective treatment group.The receiver operating characteristic(ROC)curve and area under the curve(AUC)were used to analyze the diagnostic value of ADC,CBF and Cho/Cr single and combined detection for high-grade BG and the predictive value for postoperative efficacy in BG patients.Result The ADC in the low-grade BG group was higher than that in the high-grade BG group,the CBF and Cho/Cr were lower than those in the high-grade BG group,and the differences were statistically significant(P<0.05).The AUC of ADC,CBF and Cho/Cr combined detection for the diagnosis of high-grade BG was 0.883,which was higher than those of each index single detection.The ADC in the effective treatment group was higher than that in the ineffective treatment group,the CBF and Cho/Cr were lower than those in the ineffective treatment group,and the differences were statistically significant(P<0.05).The AUC of ADC,CBF and Cho/Cr combined detection for predicting postoperative efficacy in BG patients was 0.878,which was higher than those of each index single detection.Conclusion Multimodal MRI examination can be used for preoperative grading and postoperative efficacy evaluation of BG,which has important guiding significance in the clinical diagnosis and treatment of BG.

关 键 词：脑胶质瘤 多模态MRI检查 诊断价值 术后疗效 

分 类 号：R739.41[医药卫生—肿瘤]