Weighted Zernike defocus coefficient of treatment zone is a meaningful indicator for myopia control efficacy of Ortho‑K lenses  

作　　者：Yuzhuo Fan Yan Li Kai Wang Jia Qu Mingwei Zhao 

机构地区：[1]Institute of Medical Technology,Peking University Health Science Center,Beijing 100191,China [2]Department of Ophthalmology&Clinical Center of Optometry,Peking University People’s Hospital,Beijing 100044,China [3]College of Optometry,Peking University Health Science Center,Beijing,China [4]Eye Disease and Optometry Institute,Peking University People’s Hospital,Beijing,China [5]Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases,Beijing,China [6]School of Ophthalmology and Optometry and Eye Hospital,Wenzhou Medical University,Wenzhou,Zhejiang,China

出　　处：《Eye and Vision》2024年第5期1-7,共7页眼视光学杂志（英文）

基　　金：supported by the National Natural Science Foundation of China(Grant Nos.82171092,81870684);National Key R&D Program of China(Grant No.2020YFC2008200).

摘　　要：Background:The goal of this study was to reproduce a three-dimensional representation of corneal defocus characteristics after orthokeratology(Ortho-K)treatment via an indicator defined as the weighted Zernike defocus coefficient of the treatment zone(C_(weighted defocus)).This could be used to predict the effectiveness of Ortho-K treatment quantitatively in a timely manner after the one-month visit.Methods:Seventy myopic children with axial length(AL)elongation after Ortho-K treatment(group A)and 63 myopic children with AL shortening after Ortho-K treatment(group B)were included in this one-year retrospective study.The proposed indicator was calculated by a customized MATLAB program.Multivariate binomial logistic regression and multivariate linear regression analyses were used to explore the association between AL change and the C_(weighted defocus),age,sex,and other ocular biometric parameters.Results:The 12-month AL change,age,pupil diameter,and vertical decentration of the Ortho-K lens were significantly different between the two groups.Multivariate logistic regression analysis showed that a larger C_(weighted defocus)(≥0.35 D/mm^(2))(OR:0.224;95%CI:0.078–0.646;P=0.006)was correlated with the emergence of AL shortening after orthokeratology treatment.A multivariate linear regression model showed that a greater C_(weighted defocus) was associated with slower 12-month AL elongation(β=−0.51,P=0.001).Conclusions:The C_(weighted defocus) is an effective predictive indicator of myopia control,and a larger C_(weighted defocus) may lead to slower elongation of AL.This meaningful indicator may help in the evaluation and adjustment of Ortho-K lens parameters in a timely manner and minimize the cost of clinical trial and error.

关 键 词：MYOPIA ORTHOKERATOLOGY Axial length DEFOCUS ZERNIKE 

分 类 号：R778.11[医药卫生—眼科]