Breast Milk Application as a Natural Method for Umbilical Cord Care:A Community-Label 3-Arm Pilot Clinical Trial  

作　　者：Bekalu Kassie Alemu Leltework Yismaw Wondimagegn Yibelu Bazezew Tewachew Muche Liyeh Abebaw Abeje Muluneh Gedefaye Nibret Mihretie Alekaw Sema Melese Linger Endalifer Getnet Gedefaw Azeze Gashaw Garedew Woldeamanuel Kenean Getaneh Tiaye Wing Fong Lee Yao Wang Chi Chiu Wang 

机构地区：[1]Department of Midwifery,College of Medicine and Health Sciences,Debre Markos University,Debre Markos 269,Ethiopia [2]Department of Obstetrics and Gynaecology,Faculty of Medicine,The Chinese University of Hong Kong,Hong Kong 999077,China [3]Department of Public Health,College of Medicine and Health Sciences,Debre Markos University,Debre Markos 269,Ethiopia [4]Department of Midwifery,College of Medicine and Health Sciences,Debre Tabor University,Debre Tabor 272,Ethiopia [5]School of Public Health,Faculty of Health,University of Technology Sydney,NSW 123,Australia [6]Department of Midwifery,College of Medicine and Health Sciences,Dire-Dawa University,Dire-Dawa 1362,Ethiopia [7]Department of Human Nutrition,College of Medicine and Health Sciences,Debre Markos University,Debre Markos 269,Ethiopia [8]Department of Midwifery,College of Medicine and Health Sciences,Injibara University,Injibara 40,Ethiopia [9]Li Ka Shing Institute of Health Sciences,The Chinese University of Hong Kong,Hong Kong 999077,China [10]School of Biomedical Sciences,Chinese University of Hong Kong-Sichuan University Joint Laboratory for Reproductive Medicine,The Chinese University of Hong Kong,Hong Kong 999077,China

出　　处：《Maternal-Fetal Medicine》2024年第4期203-210,共8页母胎医学杂志（英文）

基　　金：funded by Debre Markos University where B.K.A.,L.Y.W.,and Y.B.are employed and got the fund with grant reference number(DMU-R/T/TD//443/07/12).

摘　　要：Objective: To compare the effects of human breast milk with those of chlorhexidine and the dry method on umbilical cord separation in Ethiopia.Methods: This open-label 3-arm nonrandomized pilot clinical trial was conducted among 45 neonates(15 in each arm)with more than 630 home visits.After a standard cord cut,human breast milk,chlorhexidine,or nothing was applied once per day for 7 days.The primary outcome was the duration of cord separation,while the secondary outcomes were umbilical cord infection,neonatal fever,jaundice,feeding and breathing difficulty,and persistent crying.Results: There were statistically significant differences in the time-to-cord separation between the human breast milk group and the chlorhexidine(P<0.001)and dry alone(P=0.038)groups.Compared to those of chlorhexidine,the rates of cord separation among human breast milk and the dry-alone group were 16.02,with 95%confidence intervals(3.81,37.43;P<0.001)and 3.15(0.99,10.00;P=0.052),respectively.One(6.7%)cord site infection was observed in the dry-alone groups only.Conclusion: This community-label study indicated that human breast milk application significantly shortened the length of umbilical cord separation time compared to chlorhexidine and dry methods.A large-scale randomized controlled trial is needed to confirm these results.

关 键 词：CHLORHEXIDINE Human breast milk Neonatal care TRIAL Umbilical cord 

分 类 号：R714[医药卫生—妇产科学]