门静脉肝窦血管病临床病理特征及研究进展  

Clinicopathological features and new advancement of porto-sinusoidal vascular disease

作　　者：董思晗 赵新颜[2] DONG Sihan;ZHAO Xinyan(Capital Medical University School of Basic Medical Sciences,Beijing,100069,China;Liver Research Center,Beijing Friendship Hospital,Capital Medical University)

机构地区：[1]首都医科大学基础医学院,北京100069 [2]首都医科大学附属北京友谊医院肝病中心

出　　处：《中国中西医结合消化杂志》2024年第12期1051-1055,共5页Chinese Journal of Integrated Traditional and Western Medicine on Digestion

摘　　要：门静脉肝窦血管病(porto-sinusoidal vascular disease,PSVD)是一种以门静脉高压为特征的肝血管疾病,近年来PSVD确诊病例数量逐年增加。通过回顾近期文献,本综述旨在阐述从特发性非肝硬化性门静脉高压到PSVD的概念变迁;介绍PSVD的主要病理特征及鉴别诊断要点;介绍无创性筛查方法,如腹部影像和瞬时弹性成像特征;探讨与PSVD相关的免疫因素、药物及遗传疾病等相关因素;还介绍了PSVD目前的治疗进展,并对其不同预后进行描述。未来需要更多研究以明确其致病机制及探索新的治疗方法。Porto-sinusoidal vascular disease(PSVD)is a hepatic vascular disease characterized by portal hypertension.In recent years,the number of confirmed cases of PSVD has been increasing annually.This review aims to summarize the evolution of the concept from idiopathic non-cirrhotic portal hypertension to PSVD,highlight the main pathological features of PSVD,and discuss key points for differential diagnosis.The review also discusses non-invasive diagnostic approaches,including abdominal imaging and transient elastography,and explores factors related to PSVD,including immune factors,medications,and genetic diseases.In addition,the current treatment progress and its different prognosis are introduced.Future research is needed to clarify the underlying pathogenic mechanisms and explore new treatment approaches for PSVD.

关 键 词：门静脉肝窦血管病 病理特征 诊断 预后 

分 类 号：R575[医药卫生—消化系统]