奥沙利铂引起门静脉肝窦血管病诊治1例  

The case report:Diagnosis and treatment of porto-sinusoidal vascular disease caused by oxaliplatin

作　　者：李容容 李盟 孙鑫 邢枫 刘成海 LI Rongrong;LI Meng;SUN Xin;XING Feng;LIU Chenghai(Institute of Liver Diseases,Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai,201203,China;Shanghai Key Laboratory of Traditional Chinese Clinical Medicine;Key Laboratory of Liver and Kidney Diseases,Ministry of Education)

机构地区：[1]上海中医药大学附属曙光医院肝病研究所,上海201203 [2]上海市中医临床重点实验室 [3]肝肾疾病病证教育部重点实验室

出　　处：《中国中西医结合消化杂志》2024年第12期1082-1086,共5页Chinese Journal of Integrated Traditional and Western Medicine on Digestion

基　　金：上海市中医药事业发展三年行动计划[No:ZY(2018-2020)-CCCX-5001];上海市科学技术委员会科技计划项目(No:20Z21900100);上海市临床重点专科建设项目(No:shslczdzk01201)。

摘　　要：奥沙利铂(oxaliplatin,OXA)为第3代铂类抗癌药,广泛应用于中晚期结直肠癌、肝癌及胃癌等的治疗,但可引起肝脏微血管病变等副作用。本文报道1例奥沙利铂引起的非肝硬化门静脉高压患者,经过肝组织病理诊断为门静脉肝窦血管病,并通过中西医结合诊治,患者临床症状与食管胃底静脉曲张得到缓解;此外,文献回顾了OXA引起门静脉肝窦血管病等肝脏微血管病变的特点。Oxaliplatin(OXA)is a third-generation platinum-based anticancer drug,which is widely used in the treatment of colorectal cancer,liver cancer and gastric cancer.However,its use can lead to several side effects,including hepatic microvascular damage.This paper reports a case of non-cirrhotic portal hypertension caused by OXA,which was diagnosed as porto-sinusoidal vascular disease by liver histopathology.The patient was successfully treated with a combination of traditional Chinese medicine and Western medicine,leading to significant clinical improvement and alleviation of esophageal and gastric varices.In addition,the literature reviewed the characteristics of hepatic microvascular disease caused by OXA.

关 键 词：奥沙利铂 门静脉肝窦血管病 肝窦内皮细胞 机制 

分 类 号：R575[医药卫生—消化系统]