基于数据挖掘探讨中医药治疗幽门螺杆菌相关性消化性溃疡的用药规律  

Medication rules of traditional Chinese medicine in treating Helicobacter pylori-related peptic ulcer based on data mining

作　　者：惠莹莹 王雅楠 马虹宇[2] 杜朋丽 李博林[5] 蔡春江[2] HUI Yingying;WANG Ya'nan;MA Hongyu;DU Pengli;LI Bolin;CAI Chunjiang(Graduate School of Tianjin University of Traditional Chinese Medicine,Tianjin,301617,China;Department of Traditional Chinese Medicine,Hebei General Hospital;School of Basic Medicine,Hebei University of Traditional Chinese Medicine;Department of Gastroenterology,Hebei Provincial of Traditional Chinese Medicine;Research Center of Hebei Provincial Hospital of Traditional Chinese Medicine)

机构地区：[1]天津中医药大学研究生院,天津301617 [2]河北省人民医院中医科 [3]河北中医药大学基础医学院 [4]河北省中医院消化内科 [5]河北省中医院科研中心

出　　处：《中国中西医结合消化杂志》2024年第12期1105-1110,共6页Chinese Journal of Integrated Traditional and Western Medicine on Digestion

基　　金：河北省中医药管理局计划项目(No:2021034、2022026)。

摘　　要：目的:运用数据挖掘技术探讨中医药治疗幽门螺杆菌(Helicobacter pylori,HP)相关性消化性溃疡(peptic ulcer,PU)的用药规律,为中药治疗HP相关性PU提供依据。方法:通过检索中国知网、维普、万方等数据库搜集中医药治疗HP相关性PU的临床研究,筛选数据并应用Excel建立数据库。运用中医传承计算平台V3.5进行统计分析及方剂分析,探讨中医药用药规律。结果:共得到中药处方391首,主要证型有脾胃虚弱型、脾胃湿热型等,使用中药191种,频次4443次,其中单次使用频次≥50次的药物为高频药物,共26种,依次为甘草、黄连、白芍、白术、海螵蛸等,高频药物功效分类以补虚类、清热类、理气类、活血化瘀类药物为主,药物四气主要以温寒并见,五味以苦、甘、辛为主,归经多属脾经、胃经、肺经、肝经,关联规则分析共得到27组常用药物组合,相关性分析得到相关系数高的19种药物组合,聚类分析得到5个药物组方。结论:该研究展示的用药规律可为临床中药治疗HP相关性PU提供一定思路。Objective:To explore the medication rules of traditional Chinese medicine(TCM)in the treatment of Helicobacter pylori(HP)-related peptic ulcer(PU)by using data mining technology,and to provide evidence and ideas for the treatment of HP-related PU.Methods:Relevant clinical studies on the treatment of HP-related PU with TCM were gathered from databases such as CNKI,VIP,and Wanfang.The data were subsequently screened,and a database was established using Excel.The Traditional Chinese Medicine Inheritance Assisted Computing Platform V3.5 was employed for statistical analysis and prescription analysis to uncover the patterns of TCM usage.Results:A total of 391 TCM prescriptions were obtained,and the main syndrome types were spleen and stomach weakness,spleen and stomach dampness-heat,etc.A tota of 191 kinds of TCM were utilized,with a frequency of 4443 times.Among them,26 kinds of drugs with a frequency xceeding 50 were considered high-frequency drugs,including licorice,Coptis chinensis,Paeoniae radix alba,Macrocephalae rhizoma,cuttlebone and so on.The high frequency drug efficacy was mainly classified as tonic drugs,clearing-heat drugs,regulating Qi drugs and blood-activating and blood-stasis-eliminating drugs.The four natures were mainly combined with warm and cold properties,and the five flavors were mainly consisted of bitterness,sweet and pungent,with the majority being classified under the spleen,stomach,lung,and liver meridians.A total of 27 groups of commonly used drug combinations were obtained by association rule analysis,and 19 drug combinations with high correlation coefficient were obtained by correlation analysis.Five drug groups were obtained by cluster analysis.Conclusion:Overall,this study provides valuable insights for the clinical treatment of HP-related PU with TCM.

关 键 词：幽门螺杆菌 消化性溃疡 中医药 用药规律 

分 类 号：R573.1[医药卫生—消化系统]