204例急性脑梗死瘀血阻络证患者危险因素分布及相关生化指标比较  

Comparison of Risk Factors Distribution and Related Biochemical Indicators in 204 Patients with Acute Cerebral Infarction with Syndrome of Static Blood Blocking Collaterals

作　　者：马钟丹妮 邓奕辉[2] MA Zhongdanni;DENG Yihui(Department of Endocrinology,Zhuhai Integrated Traditional Chinese and Western Medicine Hospital,Zhuhai 519000,China;College of Integrated Traditional Chinese and Western Medicine,Human University of Chinese Medicine,Changsha 410208,China)

机构地区：[1]广东省珠海市中西医结合医院内分泌科,广东珠海519000 [2]湖南中医药大学中西医结合学院,长沙410208

出　　处：《中西医结合研究》2024年第6期370-375,共6页Research of Integrated Traditional Chinese and Western Medicine

基　　金：国家自然科学基金面上项目(No.81874416);湖南省科技计划项目(No.2017SK4005)。

摘　　要：目的探讨急性脑梗死瘀血阻络证及其兼证与常见危险因素及相关生化指标的关联性。方法统计204例急性脑梗死瘀血阻络证患者脑血管病危险因素、中医证型分布情况,比较不同中医证型患者相关生化指标水平。结果204例急性脑梗死瘀血阻络证患者中,脑血管病危险因素占比由高到低依次为缺乏运动(83.82%)、高血压(74.51%)、年龄≥60岁(67.16%)等,中医证型占比由高到低分别为瘀血阻络兼风痰火亢证(36.76%)、瘀血阻络兼痰湿蒙神证(25.49%)、瘀血阻络兼气虚血瘀证(18.14%)等。瘀血阻络兼气虚血瘀证患者血压(blood pressure,BP)水平显著低于其他中医证型(P<0.05);瘀血阻络兼风痰火亢证患者血红蛋白(hemoglobin,HGB)水平明显高于其他中医证型(P<0.05);瘀血阻络兼风火上扰证患者白蛋白(albumin,ALB)、空腹血糖(fasting blood glucose,FBG)水平明显高于其他中医证型(P<0.05);瘀血阻络兼痰湿蒙神证患者直接胆红素(direct bilirubin,DBIL)水平明显高于其他中医证型(P<0.05);瘀血阻络证兼痰热腑实证患者总胆固醇(total cholesterol,TC)水平明显低于其他中医证型(P<0.05),高密度脂蛋白(high density lipoprotein,HDL)水平明显高于其他中医证型(P<0.05)。结论①急性脑梗死瘀血阻络证多见于60岁以上患者,缺乏运动、饮食偏颇、合并有高血压为本病的突出危险因素。②在中医证型分布上,瘀血阻络兼风痰火亢证占比最多,提示本病发病与风、痰、瘀3种致病因素密切相关。③收缩压与舒张压可作为瘀血阻络兼气虚血瘀证辨证参考指标,HGB可作为瘀血阻络兼风痰火亢证辨证参考指标,ALB、FBG可作为瘀血阻络兼风火上扰证辨证参考指标,DBIL可作为瘀血阻络兼痰湿蒙神证辨证参考指标,TC、HDL可作为瘀血阻络兼痰热腑实证辨证参考指标。Objective To explore the correlation between the syndrome of static blood blocking collaterals and its concurrent symptoms in acute cerebral infarction and common risk factors and related biochemical indicators.Methods The risk factors of cerebrovascular disease and the distribution of traditional Chinese medicine(TCM)syndrome types in 204 patients with acute cerebral infarction with syndrome of static blood blocking collat-erals were statistically analyzed,and the levels of relevant biochemical indicators in patients with different TCM syndrome types were compared.Results Among 204 patients with acute cerebral infarction with syndrome of static blood blocking collaterals,the risk factors for cerebrovascular disease ranked from high to low,including lack of exercise(83.82%),hypertension(74.51%),and age≥60 years old(67.16%).The proportion of TCM syndrome types from high to low is as follows:syndrome of static blood blocking collaterals combined with hyperactivity of wind-phlegm-fire(36.76%),syndrome of static blood blocking collaterals combined with phlegm-damp clouding orifices(25.49%),syndrome of static blood blocking collaterals combined with blood stasis due to qi deficiency(18.14%),etc.The blood pressure(BP)level of patients with syndrome of static blood blocking collaterals combined with blood stasis due to qi deficiency was significantly lower than that of other TCM syndrome types(P<0.05).The hemoglobin(HGB)level of patients with syndrome of static blood blocking collaterals combined with hyperactivity of wind-phlegm-fire was significantly higher than that of other TCM syndrome types(P<0.05).The albumin(ALB),fasting blood glucose(FBG)levels of patients with syndrome of static blood blocking collaterals combined with upward disturbance of wind-fire were significantly higher than those of other TCM syndrome types(P<0.05).The direct bilirubin(DBIL)level of patients with syndrome of static blood blocking collaterals com-bined with phlegm-damp clouding orifices was significantly higher than that of other TCM s

关 键 词：急性脑梗死 瘀血阻络证 危险因素 生化指标 中医证型 

分 类 号：R743.3[医药卫生—神经病学与精神病学]