The effect of breaking sitting time with physical activity breaks on cognitive performance in young people with cerebral palsy:an exposure response cross-over feasibility design  

作　　者：Shelly Coe Jo Cossington Johnny Collett Andy Meaney Foteini Mavrommati Yujun Ng Hooshang Izadi Will Wade Dominika M.Pindus Oliver Bushnell Luke Whaymand Tim Theologis Emily Swift Ece Akgul Sam Allen Helen Dawes 

机构地区：[1]Centre for Movement Occupational and Rehabilitation Sciences,Department of Sport Health Sciences and Social Work,Oxford Brookes University,Oxford,UK,OX30BP [2]Oxford Brookes Centre for Nutrition and Health,Department of Sport Health Sciences and Social Work,Oxford Institute for Applied Health Research,Oxford Brookes University,Oxford,UK,OX30BP [3]Medical School,University of Exeter,Exeter,UK [4]Specialised Translational Research Oxford Neuromuscular Group:STRONG,Department of Paediatrics,University of Oxford,John Radcliffe Hospital,Oxford,UK [5]Cardiovascular Medicine,University of Oxford,John Radcliffe Hospital,Oxford,UK [6]Ace Centre,Hollinwood Business Centre,Oldham,UK [7]University of Illinois at Urbana-Champaign,Department of Kinesiology and Community Health,Urbana,IL,USA [8]Beckman Institute for Advanced Science and Technology,University of Illinois at Urbana-Champaign,Urbana,IL,USA [9]Neuroscience Program,University of Illinois at Urbana-Champaign,Urbana,IL,USA [10]Nuffield Department of Orthopaedics,Rheumatology and Musculoskeletal Sciences,University of Oxford,Botnar Research Centre,Oxford,UK [11]School of Clinical Medicine,Centre for Healthy Brain Ageing(CHeBA),Discipline of Psychiatry and Mental Health,University of New South Wales,Sydney,Australia [12]NIHR Exeter BRC,University of Exeter Medical School,Department of Public Health and Sports Sciences,Faculty of Health and Life Sciences,Medical School Building,College of Medicine and Health,St Lukes Campus,Exeter,UK [13]Nuffield Department of Clinical Neurosciences,University of Oxford,Oxford,UK

出　　处：《Translational Exercise Biomedicine》2024年第1期32-42,共11页运动转化生物医学（英文）

基　　金：supported by the NIHR Exeter Health Biomedical Research Centre.The views expressed are those of the authors and not necessarily those of the NHS,the NIHR or the Department of Health.Johnny Collett is supported NIHR Oxford Health Biomedical research centre。

摘　　要：Objectives To assess the feasibility of methods and estimate the potential effect of interrupting sedentary behaviour,with intermittent or continuous physical activity breaks,on cognitive performance in young people with Cerebral Palsy.Methods A randomised three-arm exposure response cross-over design with process evaluation.Participants were recruited throughout the Thames Valley,UK between 01/11/2018 to 31/03/2020.The three 2 h activity exposure visits included:(i)sitting only(controls),(ii)sitting plus 20 min of moderate-to-vigorous activity burst,or(iii)4×5 min of moderate-to-vigorous activity bursts,during a 2.5 h sedentary session.Measures of feasibility were sought.Cognitive performance outcomes(using the Eriksen Flanker task and Forward and Backward Digit Span)were delivered before and after the 2 h testing period.Results 36 participants were randomised(age 13.2±2.7,Gross-Motor Functional Classification System 1–3).Study retention was 83%across all three interventions and overall missing data for measures was 4%.A small intervention effect was found in reaction time in the 4×5 min physical activity exposure session compared to the sedentary control condition(0.42;95%CI 0.40 to 0.79).There were two research-related minor adverse effects,an allergic reaction to the FreeStyle Libre and feeling faint and vomiting after consumption of glucose solution.Both events were resolved and participants continued with the study.Conclusions The study design and intervention implementing short bursts of physical activity was feasible and indicated a potential effect on reaction time as a measure of cognitive performance in young people with cerebral palsy.

关 键 词：cerebral palsy physical activity cognitive performance CHILD ADOLESCENT 

分 类 号：R74[医药卫生—神经病学与精神病学]