Aptamers for mycotoxin recognition in food:Recent advances and future considerations  

作　　者：Peng Fang Hao Qu Yu Mao Lei Zheng 

机构地区：[1]School of Food and Biological Engineering,Hefei University of Technology,Hefei,230009,China

出　　处：《Advanced Agrochem》2023年第3期213-220,共8页现代农业化学（英文）

基　　金：supported by the National Key Research and Devel-opment Program of China(2020YFC1606802);the National Natural Science Foundation of China(22104028);the Natural Science Foundation of Anhui Province(2108085QC139).

摘　　要：The contamination of mycotoxin in food has posed a serious threat to human health and safety.Accurate detection of mycotoxins provides a strong guarantee for food safety.Aptamers with excellent recognition capacity to mycotoxins have gained growing attention because of their high binding affinity,high specificity and low cost.They are commonly generated by an in vitro selection procedure called SELEX.However,the existing performance of mycotoxin aptamers are not good enough in complex food matrix,and the success rate of SELEX still need to be improved.The employment of efficient SELEX strategies for the generation of better mycotoxin aptamers is significantly important.This article has reviewed different SELEX approaches conducted for mycotoxin aptamer generation.Furthermore,the properties of various mycotoxin aptamers have been discussed.Finally,challenges and future considerations for mycotoxin aptamer selection are summarized,and their strengths and limitations in food safety application are highlighted.

关 键 词：APTAMER SELEX In vitro selection MYCOTOXIN Food safety 

分 类 号：Q78[生物学—分子生物学]