系统性免疫炎症指数和血清糖钾比值对老年一氧化碳中毒后迟发性脑病的预测价值  

The Predictive Value of Systemic Immune-inflammation Index and Serum Glucose-potassium Ratio in Elderly Patients with Delayed Encephalopathy after Carbon Monoxide Poisoning

作　　者：刘洋[1] 闻晓庆 景少巍 骆图南 马遥 罗昕[1] 王艳秋 陈功财 欧阳晓春 LIU Yang;WEN Xiao-qing;JING Shao-wei;LUO Tu-nan;MA Yao;LUO Xin;WANG Yan-qiu;CHEN Gong-cai;OUYANG Xiao-chun(Department of Neurology,the 908^(th)Hospital of the Chinese People’s Liberation Army Joint Logistic Support Force,Nanchang 330002,China;The First Stationed Outpatient Department,the 908^(th)Hospital of the Chinese People’s Liberation Army Joint Logistic Support Force,Nanchang 330002,China)

机构地区：[1]中国人民解放军联勤保障部队第九〇八医院神经内科,南昌330002 [2]中国人民解放军联勤保障部队第九〇八医院第一派驻门诊部,南昌330002

出　　处：《南昌大学学报（医学版）》2024年第6期80-84,96,共6页Journal of Nanchang University：Medical Sciences

基　　金：江西省卫健委科技项目(20204803)。

摘　　要：目的探讨系统性免疫炎症指数、血清糖钾比值对老年一氧化碳中毒后迟发性脑病患者的预测作用。方法对2010—2023年中国人民解放军联勤保障部队第九〇八医院收治的96例老年(>60岁)急性一氧化碳中毒患者的临床资料进行回顾性分析,其中一氧化碳中毒后发展为迟发性脑病38例(A组)、未发展为迟发性脑病58例(B组)。收集2组患者的红细胞计数、血红蛋白、白细胞计数、中性粒细胞计数、淋巴细胞计数、血小板计数、血糖、血钾资料,计算系统性免疫炎症指数(SIII)和血清糖钾比值(G/K)。使用受试者工作特征曲线(ROC)计算曲线下面积(AUC),分析SIII和G/K对一氧化碳中毒后迟发性脑病的预测价值。结果2组患者的白细胞计数、中性粒细胞计数、淋巴细胞计数、血小板计数、SIII、血糖、G/K比较差异均有统计学意义(P<0.05)。一氧化碳中毒后迟发性脑病最有效的预测因子是SIII值(AUC=0.859,截止值>1666.75,灵敏度=0.842,特异性=0.759),其次为G/K值(AUC=0.797,截止值>29.87,灵敏度=0.789,特异性=0.724)。结论SIII及G/K值能较好地预测老年人一氧化碳中毒后是否发展为迟发性脑病,早期获得SIII及G/K值,有助于临床采取针对性的干预措施预防一氧化碳中毒后迟发性脑病的发生。Objective To investigate the predictive value of systemic immune-inflammation index and serum glucose-potassium ratio in elderly patients with delayed encephalopathy after carbon monoxide poisoning.Methods A retrospective analysis was conducted on the clinical data of 96 elderly patients(>60 years old)with acute carbon monoxide poisoning admitted to the 908th Hospital of the Chinese People’s Liberation Army Joint Logistic Support Force from 2010 to 2023.Among them,38 patients developed delayed encephalopathy after carbon monoxide poisoning(Group A),and 58 patients did not(Group B).Data on red blood cell count,hemoglobin,white blood cell count,neutrophil count,lymphocyte count,platelet count,blood glucose,and blood potassium were collected from both groups of patients,and the systemic immune-inflammation index(SIII)and serum glucose-potassium ratio(G/K)were calculated.The predictive value of SIII and G/K for delayed encephalopathy after carbon monoxide poisoning was analyzed by calculating the area under the curve using the receiver operating characteristic curve.Results There were statistically significant differences in white blood cell count,neutrophil count,lymphocyte count,platelet count,SIII,blood glucose,and G/K between the 2 groups of patients(P<0.05).The most effective predictor of delayed encephalopathy after carbon monoxide poisoning was the SIII value(AUC=0.859,cut-off value>1666.75,sensitivity=0.842,specificity=0.759),followed by the G/K value(AUC=0.797,cut-off value>29.87,sensitivity=0.789,specificity=0.724).Conclusion The values of SIII and G/K are potential predictors of whether elderly patients will develop delayed encephalopathy after carbon monoxide poisoning,and the early acquisition of SIII and G/K values can assist clinicians in taking targeted intervention measures to prevent the occurrence of delayed encephalopathy after carbon monoxide poisoning.

关 键 词：一氧化碳中毒 迟发性脑病 系统性免疫炎症指数 血清糖钾比值 

分 类 号：R742[医药卫生—神经病学与精神病学]